DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Zhang, Q | - |
dc.contributor.author | Jo, S | - |
dc.contributor.author | Chai, SC | - |
dc.contributor.author | Oh, M | - |
dc.contributor.author | Im, W | - |
dc.contributor.author | Lu, H | - |
dc.contributor.author | Lim, HS | - |
dc.date.accessioned | 2016-03-31T09:13:48Z | - |
dc.date.available | 2016-03-31T09:13:48Z | - |
dc.date.created | 2012-02-13 | - |
dc.date.issued | 2011-02-02 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.other | 2011-OAK-0000024737 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16856 | - |
dc.description.abstract | There is considerable interest in developing non-peptidic, small-molecule alpha-helix mimetics to disrupt alpha-helix-mediated protein protein interactions. Herein, we report the design of a novel pyrrolopyrimidine-based scaffold for such alpha-helix mimetics with increased conformational rigidity. We also developed a facile solid-phase synthetic route that is amenable to divergent synthesis of a large library. Using a fluorescence polarization-based assay, we identified cell-permeable, dual MDMX/MDM2 inhibitors, demonstrating that the designed molecules can act as alpha-helix mimetics. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.subject | SMALL-MOLECULE INHIBITORS | - |
dc.subject | STRUCTURE-BASED DESIGN | - |
dc.subject | BETA(3)-PEPTIDE INHIBITORS | - |
dc.subject | P53 PATHWAY | - |
dc.subject | IN-VIVO | - |
dc.subject | MDMX | - |
dc.subject | AFFINITY | - |
dc.subject | ANTAGONISTS | - |
dc.subject | SCAFFOLDS | - |
dc.subject | LIBRARIES | - |
dc.title | Novel Pyrrolopyrimidine-Based alpha-Helix Mimetics: Cell-Permeable Inhibitors of Protein-Protein Interactions | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1021/JA108230S | - |
dc.author.google | Lee, JH | - |
dc.author.google | Zhang, Q | - |
dc.author.google | Jo, S | - |
dc.author.google | Chai, SC | - |
dc.author.google | Oh, M | - |
dc.author.google | Im, W | - |
dc.author.google | Lu, H | - |
dc.author.google | Lim, HS | - |
dc.relation.volume | 133 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 676 | - |
dc.relation.lastpage | 679 | - |
dc.contributor.id | 10115917 | - |
dc.relation.journal | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.133, no.4, pp.676 - 679 | - |
dc.identifier.wosid | 000287295300010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 679 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 676 | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 133 | - |
dc.contributor.affiliatedAuthor | Lim, HS | - |
dc.identifier.scopusid | 2-s2.0-79851497821 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 73 | - |
dc.description.scptc | 85 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SMALL-MOLECULE INHIBITORS | - |
dc.subject.keywordPlus | STRUCTURE-BASED DESIGN | - |
dc.subject.keywordPlus | BETA(3)-PEPTIDE INHIBITORS | - |
dc.subject.keywordPlus | P53 PATHWAY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MDMX | - |
dc.subject.keywordPlus | AFFINITY | - |
dc.subject.keywordPlus | ANTAGONISTS | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | LIBRARIES | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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