Current status of the metabolic engineering of microorganisms for biohydrogen production
SCIE
SCOPUS
- Title
- Current status of the metabolic engineering of microorganisms for biohydrogen production
- Authors
- Oh, YK; Raj, SM; Jung, GY; Park, S
- Date Issued
- 2011-09
- Publisher
- ELSEVIER SCI LTD
- Abstract
- The improvement of H-2 production capabilities of hydrogen (H-2)-producing microorganisms is a challenging issue. Microorganisms have evolved for fast growth and substrate utilization rather than H-2 production. To develop good H-2-producing biocatalysts, many studies have focused on the redirection and/or reconstruction of cellular metabolisms. These studies included the elimination of enzymes and carbon pathways interfering or competing with H-2 production, the incorporation of non-native metabolic pathways leading to H-2 production, the utilization of various carbon substrates, the rectification of H-2-producting enzymes (nitrogenase and hydrogenase) and photophosphorylation systems, and in silico pathway flux analysis, among others. Owing to these studies, significant improvements in the yield and rate of H-2 production, and in the stability of H-2 production activity, were reached. This review presents and discusses the recent developments in biohydrogen production, with a focus on metabolic pathway engineering. (C) 2011 Elsevier Ltd. All rights reserved.
- Keywords
- Biohydrogen; Metabolic engineering; Biophotolysis; Photofermentation; Dark fermentation; ENHANCED HYDROGEN-PRODUCTION; ESCHERICHIA-COLI STRAINS; RHODOBACTER-SPHAEROIDES; H-2 PRODUCTION; FLUX ANALYSIS; THERMOCOCCUS-KODAKARAENSIS; HYPERTHERMOPHILIC ARCHAEON; CHLAMYDOMONAS-REINHARDTII; CLOSTRIDIUM-TYROBUTYRICUM; ENTEROBACTER-AEROGENES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16859
- DOI
- 10.1016/J.BIORTECH.2011.04.054
- ISSN
- 0960-8524
- Article Type
- Article
- Citation
- BIORESOURCE TECHNOLOGY, vol. 102, no. 18, page. 8357 - 8367, 2011-09
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