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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Y | - |
| dc.contributor.author | Samaco, RC | - |
| dc.contributor.author | Gatchel, JR | - |
| dc.contributor.author | Thaller, C | - |
| dc.contributor.author | Orr, HT | - |
| dc.contributor.author | Zoghbi, HY | - |
| dc.date.accessioned | 2016-03-31T09:15:44Z | - |
| dc.date.available | 2016-03-31T09:15:44Z | - |
| dc.date.created | 2012-02-06 | - |
| dc.date.issued | 2008-10 | - |
| dc.identifier.issn | 1097-6256 | - |
| dc.identifier.other | 2008-OAK-0000024642 | - |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16909 | - |
| dc.description.abstract | Spinocerebellar ataxia type 1 is caused by expansion of a translated CAG repeat in ataxin1 (ATXN1). The level of the polyglutamine-expanded protein is one of the factors that contributes to disease severity. Here we found that miR-19, miR-101 and miR-130 co-regulate ataxin1 levels and that their inhibition enhanced the cytotoxicity of polyglutamine-expanded ATXN1 in human cells. We provide a new candidate mechanism for modulating the pathogenesis of neurodegenerative diseases sensitive to protein dosage. | - |
| dc.description.statementofresponsibility | X | - |
| dc.language | English | - |
| dc.publisher | nature publishing group | - |
| dc.relation.isPartOf | Nature Neuroscience | - |
| dc.subject | SPINOCEREBELLAR ATAXIA TYPE-1 | - |
| dc.subject | TRANSGENIC MICE | - |
| dc.subject | TRINUCLEOTIDE REPEAT | - |
| dc.subject | NEURODEGENERATION | - |
| dc.subject | EXPANSION | - |
| dc.subject | MICRORNAS | - |
| dc.subject | MODEL | - |
| dc.title | miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis | - |
| dc.type | Article | - |
| dc.contributor.college | 생명과학과 | - |
| dc.identifier.doi | 10.1038/NN.2183 | - |
| dc.author.google | Lee, Y | - |
| dc.author.google | Samaco, RC | - |
| dc.author.google | Gatchel, JR | - |
| dc.author.google | Thaller, C | - |
| dc.author.google | Orr, HT | - |
| dc.author.google | Zoghbi, HY | - |
| dc.relation.volume | 11 | - |
| dc.relation.issue | 10 | - |
| dc.relation.startpage | 1137 | - |
| dc.relation.lastpage | 1139 | - |
| dc.contributor.id | 10143380 | - |
| dc.relation.journal | Nature Neuroscience | - |
| dc.relation.index | SCI급, SCOPUS 등재논문 | - |
| dc.relation.sci | SCI | - |
| dc.collections.name | Journal Papers | - |
| dc.type.rims | ART | - |
| dc.identifier.bibliographicCitation | Nature Neuroscience, v.11, no.10, pp.1137 - 1139 | - |
| dc.identifier.wosid | 000259528500007 | - |
| dc.date.tcdate | 2019-01-01 | - |
| dc.citation.endPage | 1139 | - |
| dc.citation.number | 10 | - |
| dc.citation.startPage | 1137 | - |
| dc.citation.title | Nature Neuroscience | - |
| dc.citation.volume | 11 | - |
| dc.contributor.affiliatedAuthor | Lee, Y | - |
| dc.identifier.scopusid | 2-s2.0-52949137369 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalClass | 1 | - |
| dc.description.wostc | 145 | - |
| dc.description.scptc | 147 | * |
| dc.date.scptcdate | 2018-05-121 | * |
| dc.type.docType | Article | - |
| dc.subject.keywordPlus | SPINOCEREBELLAR ATAXIA TYPE-1 | - |
| dc.subject.keywordPlus | TRANSGENIC MICE | - |
| dc.subject.keywordPlus | TRINUCLEOTIDE REPEAT | - |
| dc.subject.keywordPlus | NEURODEGENERATION | - |
| dc.subject.keywordPlus | EXPANSION | - |
| dc.subject.keywordPlus | MICRORNAS | - |
| dc.subject.keywordPlus | MODEL | - |
| dc.relation.journalWebOfScienceCategory | Neurosciences | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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- 이윤태LEE, YOON TAE
- Dept of Life Sciences