An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices
SCIE
SCOPUS
- Title
- An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices
- Authors
- Chen, RJ; Choi, HC; Bangsaruntip, S; Yenilmez, E; Tang, XW; Wang, Q; Chang, YL; Dai, HJ
- Date Issued
- 2004-02-11
- Publisher
- AMER CHEMICAL SOC
- Abstract
- It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenon that can be exploited for label-free detection of biomolecules with a high potential for miniaturization. This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selected components of the devices from protein adsorption, self-assembled monolayers (SAMS) of methoxy(poly-(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants on the nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the electronic biosensing signal than adsorption solely along the exposed lengths of the nanotubes.
- Keywords
- MODEL ELECTROCHEMICAL INTERFACES; SELF-ASSEMBLED MONOLAYERS; INFRARED-SPECTROSCOPY; ULTRAHIGH-VACUUM; SENSORS; FUNCTIONALIZATION; BIOSENSORS; SOLVATION; SURFACES; PT(111)
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16923
- DOI
- 10.1021/JA038702M
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , vol. 126, no. 5, page. 1563 - 1568, 2004-02-11
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