CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma
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SCOPUS
- Title
- CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma
- Authors
- Piao, LS; Hur, W; Kim, TK; Hong, SW; Kim, SW; Choi, JE; Sung, PS; Song, MJ; Lee, BC; Hwang, D; Yoon, SK
- Date Issued
- 2012-02-28
- Publisher
- Amsterdam, Elsevier/North-Holland
- Abstract
- CD133 is a cancer stem-cell (CSC) marker associated with radioresistance and chemoresistance in various cancers. In the present study, CD133-expressing liver cancer cells following radiation exposure showed higher activation of MAPK/PI3K signaling pathway and reduction in reactive oxygen species levels compared to CD133(-) cells. The in vivo study with a xenograft model showed increased tumor formation in irradiated CD133(+) cell-injected nude mice compared to the CD133(-) group, suggesting that CD133 contributes to radioresistance in HCC. Therefore, CD133-expressing liver cancer cells have anti-apoptotic and radioresistance properties that may be useful to improve anti-cancer treatments, including chemotherapy/radiotherapy of HCC. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
- Keywords
- Hepatocellular carcinoma; Cancer stem cell; Radioresistance; CD133; Microarray; HEMATOPOIETIC STEM; IDENTIFICATION; EXPRESSION; RADIATION; INHIBITION; PROLIFERATION; ACTIVATION; APOPTOSIS; MARKERS; TUMOR
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17024
- DOI
- 10.1016/J.CANLET.2011.10.012
- ISSN
- 0304-3835
- Article Type
- Article
- Citation
- CANCER LETTERS, vol. 315, no. 2, page. 129 - 137, 2012-02-28
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- There are no files associated with this item.
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