DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung Woo Heo | - |
dc.contributor.author | Tae Su Choi | - |
dc.contributor.author | Kyung man Park | - |
dc.contributor.author | Young Ho Ko | - |
dc.contributor.author | Seung Bin Kim | - |
dc.contributor.author | Kimoon Kim | - |
dc.contributor.author | Kim, HI | - |
dc.date.accessioned | 2016-03-31T09:20:22Z | - |
dc.date.available | 2016-03-31T09:20:22Z | - |
dc.date.created | 2011-10-18 | - |
dc.date.issued | 2011-10-15 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.other | 2011-OAK-0000024409 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17033 | - |
dc.description.abstract | The gas phase host-guest chemistry between cucurbit[6]uril (CB[6]) and peptide is investigated using electrospray ionization mass spectrometry (ESI-MS). CB[6] exhibits a high preference to interacting with a Lys residue in a peptide forming a CB[6]-peptide complex. Collisionally activated CB[6] complexes of peptides yield a common highly selective fragment product at m/z 549.2, corresponding to the doubly charged CB[6] complex of 5-iminiopentylammonium (STPA). The process involves the formation of an internal iminium ion, which results from further fragments to an a-type ion from a y-type ion, and the resulting 5IPA ion threads through CB[6]. Numerous peptides are investigated to test the generality of the observed unique host-guest chemistry of CB[6]. Its potential utility in probing protein structures is demonstrated using CB[6] complexes of ubiquitin. Low-energy collision induced dissociation yields CB[6] complex fragments, and further MS(n) spectra reveal details of the CB[6] binding sites, which allow us to deduce the protein structure in the solution phase. The mechanisms and energetics of the observed reactions are evaluated using density functional theory calculations. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ANALYTICAL CHEMISTRY | - |
dc.title | Host–Guest Chemistry in the Gas Phase: Selected Fragmentations of CB[6]–Peptide Complexes at Lysine Residues and Its Utility to Probe the Structures of Small Proteins | - |
dc.type | Article | - |
dc.contributor.college | 첨단재료과학부 | - |
dc.identifier.doi | 10.1021/AC201854A | - |
dc.author.google | Heo, SW | - |
dc.author.google | Choi, TS | - |
dc.author.google | Park, KM | - |
dc.author.google | Ko, YH | - |
dc.author.google | Kim, SB | - |
dc.author.google | Kim, K | - |
dc.author.google | Kim, HI | - |
dc.relation.volume | 83 | - |
dc.relation.issue | 20 | - |
dc.relation.startpage | 7916 | - |
dc.relation.lastpage | 7923 | - |
dc.contributor.id | 10104366 | - |
dc.relation.journal | ANALYTICAL CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ANALYTICAL CHEMISTRY, v.83, no.20, pp.7916 - 7923 | - |
dc.identifier.wosid | 000295817500048 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 7923 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 7916 | - |
dc.citation.title | ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 83 | - |
dc.contributor.affiliatedAuthor | Kimoon Kim | - |
dc.contributor.affiliatedAuthor | Kim, HI | - |
dc.identifier.scopusid | 2-s2.0-80054684751 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 35 | - |
dc.description.scptc | 33 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SURFACE-INDUCED DISSOCIATION | - |
dc.subject.keywordPlus | MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | SUPRAMOLECULAR ASSEMBLIES | - |
dc.subject.keywordPlus | NONCOVALENT ATTACHMENT | - |
dc.subject.keywordPlus | MOLECULAR RECOGNITION | - |
dc.subject.keywordPlus | POLYALANINE PEPTIDES | - |
dc.subject.keywordPlus | ESI-MS | - |
dc.subject.keywordPlus | CUCURBITURIL | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | CHARGE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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