Well-Defined DNA-Mimic Brush Polymers Bearing Adenine Moieties: Synthesis, Layer-by-Layer Self-Assembly, and Biocompatibility
SCIE
SCOPUS
- Title
- Well-Defined DNA-Mimic Brush Polymers Bearing Adenine Moieties: Synthesis, Layer-by-Layer Self-Assembly, and Biocompatibility
- Authors
- Jin Chul Kim; Jungwoon Jung; Yecheol Rho; Mihee Kim; Wonsang Kwon; Heesoo Kim; Ik Jung Kim; Jung Ran Kim; Ree, M
- Date Issued
- 2011-07
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Two new DNA-mimicking brush polymers were synthesized: poly[oxy(11-(3-(9-adeninyl)propionato)-undecanyl-1-thiomethyl)ethylene] (PECH-AS) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl)ethylene] (PECH-AS). These polymers were found to be thermally stable up to 220 degrees C and could be applied easily by conventional coating processes to produce good quality films. Interestingly, both brush polymers formed molecular multibilayer structures to provide an adenine-rich surface. Despite the structural similarities, PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. These differences were attributed to the chemical structures in the bristles of the polymers. The adenine-rich surfaces of the polymer films demonstrated selective protein adsorption, suppressed bacterial adherence, facilitated HEp-2 cell adhesion, and exhibited good biocompatibility in mice. However, the high hydrophilicity and good water sorption characteristics of the PECH-AS film suggest that this brush polymer is better suited to applications requiring good biocompatibility and reduced chance of bacterial infection compared with the PECH-AP film.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17293
- DOI
- 10.1021/BM200572T
- ISSN
- 1525-7797
- Article Type
- Article
- Citation
- BIOMACROMOLECULES, vol. 12, no. 7, page. 2822 - 2833, 2011-07
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