DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J | - |
dc.contributor.author | Lee, Y | - |
dc.contributor.author | Singha, K | - |
dc.contributor.author | Kim, HW | - |
dc.contributor.author | Shin, JH | - |
dc.contributor.author | Jo, S | - |
dc.contributor.author | Han, DK | - |
dc.contributor.author | Kim, WJ | - |
dc.date.accessioned | 2016-03-31T09:34:50Z | - |
dc.date.available | 2016-03-31T09:34:50Z | - |
dc.date.created | 2011-07-11 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.other | 2011-OAK-0000023760 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17359 | - |
dc.description.abstract | In recent years, numerous research activities have been devoted to the controlled release of nitric oxide (NO) due to its potential as a restenosis inhibitor which inhibits the proliferation of vascular smooth muscle cells, the apoptosis of vascular endothelial cells, and aggregation of platelets. This work has demonstrated the development of a novel NO-conjugated gel system comprising of thermosensitive Pluronic F127, branched polyethylenimine (BPEI), and diazeniumdiolates (NONOates). Synthesis of conjugated Pluronic-BPEI-NONOates involved coupling of activated F127 to BPEI followed by the installation of NONOates at the secondary amine sites of branched PEI backbone under high pressure. NO-conjugated gel system, F127-BPEI-NONOates, reduced the initial burst of NO release and prolonged NO release. Furthermore, F127-BPEI-NONOates polymer coated on cell culture dish displayed much higher increase of endothelial cell proliferation and reduction of smooth muscle cell proliferation than that exhibited by non-NO releasing control. Such an NO-releasing device can operate locally and has a great potential in several biomedical applications due to high biocompatibility imparted by the conjugated F127. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | BIOCONJUGATE CHEMISTRY | - |
dc.subject | SILICA NANOPARTICLES | - |
dc.subject | POLY(VINYL ALCOHOL) | - |
dc.subject | PLATELET-ADHESION | - |
dc.subject | BLOCK-COPOLYMERS | - |
dc.subject | RESTENOSIS | - |
dc.subject | DONOR | - |
dc.subject | INDUCTION | - |
dc.subject | POLYMERS | - |
dc.subject | SCAFFOLD | - |
dc.subject | DELIVERY | - |
dc.title | NONOates-Polyethylenimine Hydrogel for Controlled Nitric Oxide Release and Cell Proliferation Modulation | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1021/BC100405C | - |
dc.author.google | Kim, J | - |
dc.author.google | Lee, Y | - |
dc.author.google | Singha, K | - |
dc.author.google | Kim, HW | - |
dc.author.google | Shin, JH | - |
dc.author.google | Jo, S | - |
dc.author.google | Han, DK | - |
dc.author.google | Kim, WJ | - |
dc.relation.volume | 22 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 1031 | - |
dc.relation.lastpage | 1038 | - |
dc.contributor.id | 10135304 | - |
dc.relation.journal | BIOCONJUGATE CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCONJUGATE CHEMISTRY, v.22, no.6, pp.1031 - 1038 | - |
dc.identifier.wosid | 000291568200007 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1038 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1031 | - |
dc.citation.title | BIOCONJUGATE CHEMISTRY | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Kim, WJ | - |
dc.identifier.scopusid | 2-s2.0-79959256071 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 33 | - |
dc.description.scptc | 31 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | POLY(VINYL ALCOHOL) | - |
dc.subject.keywordPlus | PLATELET-ADHESION | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | RESTENOSIS | - |
dc.subject.keywordPlus | DONOR | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
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