DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, YB | - |
dc.contributor.author | Li, HL | - |
dc.contributor.author | Kassabov, SR | - |
dc.contributor.author | Jin, I | - |
dc.contributor.author | Puthanveettil, SV | - |
dc.contributor.author | Karl, KA | - |
dc.contributor.author | Lu, Y | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Bailey, CH | - |
dc.contributor.author | K | - |
dc.contributor.author | el, ER | - |
dc.date.accessioned | 2016-03-31T09:36:57Z | - |
dc.date.available | 2016-03-31T09:36:57Z | - |
dc.date.created | 2011-06-16 | - |
dc.date.issued | 2011-05-12 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.other | 2011-OAK-0000023684 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17401 | - |
dc.description.abstract | Neurexin and neuroligin, which undergo heterophilic interactions with each other at the synapse, are mutated in some patients with autism spectrum disorder, a set of disorders characterized by deficits in social and emotional learning. We have explored the role of neurexin and neuroligin at sensory-to-motor neuron synapses of the gill-withdrawal reflex in Aplysia, which undergoes sensitization, a simple form of learned fear. We find that depleting neurexin in the presynaptic sensory neuron or neuroligin in the postsynaptic motor neuron abolishes both long-term facilitation and the associated presynaptic growth induced by repeated pulses of serotonin. Moreover, introduction into the motor neuron of the R451C mutation of neuroligin-3 linked to autism spectrum disorder blocks both intermediate-term and long-term facilitation. Our results suggest that activity-dependent regulation of the neurexin-neuroligin interaction may govern transsynaptic signaling required for the storage of long-term memory, including emotional memory that may be impaired in autism spectrum disorder. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | NEURON | - |
dc.subject | LOCAL PROTEIN-SYNTHESIS | - |
dc.subject | ADHESION MOLECULES | - |
dc.subject | ALPHA-NEUREXINS | - |
dc.subject | BETA-NEUREXINS | - |
dc.subject | MOTOR SYNAPSES | - |
dc.subject | MEMORY STORAGE | - |
dc.subject | PLASTICITY | - |
dc.subject | AUTISM | - |
dc.subject | GENES | - |
dc.subject | INTERMEDIATE | - |
dc.title | Neurexin-Neuroligin Transsynaptic Interaction Mediates Learning-Related Synaptic Remodeling and Long-Term Facilitation in Aplysia | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.NEURON.2011.03.020 | - |
dc.author.google | Choi, YB | - |
dc.author.google | Li, HL | - |
dc.author.google | Kassabov, SR | - |
dc.author.google | Jin, I | - |
dc.author.google | Puthanveettil, SV | - |
dc.author.google | Karl, KA | - |
dc.author.google | Lu, Y | - |
dc.author.google | Kim, JH | - |
dc.author.google | Bailey, CH | - |
dc.author.google | Kandel, ER | - |
dc.relation.volume | 70 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 468 | - |
dc.relation.lastpage | 481 | - |
dc.contributor.id | 10114767 | - |
dc.relation.journal | NEURON | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NEURON, v.70, no.3, pp.468 - 481 | - |
dc.identifier.wosid | 000290926100009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 481 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 468 | - |
dc.citation.title | NEURON | - |
dc.citation.volume | 70 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.identifier.scopusid | 2-s2.0-79955672523 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 60 | - |
dc.description.scptc | 60 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LOCAL PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | ADHESION MOLECULES | - |
dc.subject.keywordPlus | ALPHA-NEUREXINS | - |
dc.subject.keywordPlus | BETA-NEUREXINS | - |
dc.subject.keywordPlus | MOTOR SYNAPSES | - |
dc.subject.keywordPlus | MEMORY STORAGE | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | AUTISM | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | INTERMEDIATE | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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