Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter
SCIE
SCOPUS
KCI
- Title
- Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter
- Authors
- Im, J; Maiti, KK; Kim, W; Kim, KT; Chung, SK
- Date Issued
- 2011-04-20
- Publisher
- KOREAN CHEMICAL SOC
- Abstract
- The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB.
- Keywords
- Quantum dot; Molecular transporter; Internalization; Macropinocytosis; Blood-brain barrier; LIVING CELLS; PENETRATING PEPTIDES; INTRACELLULAR DELIVERY; TAT PEPTIDE; LONG-TERM; TRACKING; MACROPINOCYTOSIS; INTERNALIZATION; NANOPARTICLES; FLUORESCENCE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17409
- DOI
- 10.5012/BKCS.2011.32.4.1282
- ISSN
- 0253-2964
- Article Type
- Article
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 32, no. 4, page. 1282 - 1292, 2011-04-20
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.