DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, SJ | - |
dc.contributor.author | Kim, DJ | - |
dc.contributor.author | Baek, KH | - |
dc.contributor.author | Yun, YD | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T12:40:52Z | - |
dc.date.available | 2016-03-31T12:40:52Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2004-01-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2004-OAK-0000003892 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18192 | - |
dc.description.abstract | IL-23 is a heterodimeric cytokine consisting of p19 and the p40 subunit of IL-12. IL-23 has been shown to possess IL-12-like biological activities, but is different in its capacity to stimulate memory T cells in vitro. In this study, we investigated whether IL-23 could influence envelope protein 2 (E2)-specific cell-mediated immunity induced by immunization of hepatitis C virus E2 DNA. We found that IL-23 induced long-lasting Th1 and CTL immune responses to E2, which are much stronger than IL-12-mediated immune responses. Interestingly, IL-23N220L, an N-glycosylation mutant showing reduced expression of excess p40 without changing the level of IL-23, exhibited a higher ratio of IFN-gamma- to IL-4-producing CD4(+) T cell frequency than did wild-type IL-23, suggesting a negative regulatory effect of p40 on Th1-prone immune response induced by IL-23. These data suggest that IL-23, particularly IL-23N220L, would be an effective adjuvant of DNA vaccine for the induction of durable Ag-specific T cell immunity. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | CD8(+) T-CELLS | - |
dc.subject | IN-VIVO | - |
dc.subject | CELLULAR-IMMUNITY | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | GENE-THERAPY | - |
dc.subject | MEMORY | - |
dc.subject | INTERLEUKIN-12 | - |
dc.subject | MURINE | - |
dc.subject | VACCINATION | - |
dc.subject | CYTOKINE | - |
dc.title | IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.172.1.525 | - |
dc.author.google | Ha, SJ | - |
dc.author.google | Kim, DJ | - |
dc.author.google | Baek, KH | - |
dc.author.google | Yun, YD | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 172 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 525 | - |
dc.relation.lastpage | 531 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.172, no.1, pp.525 - 531 | - |
dc.identifier.wosid | 000187427700065 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 531 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 525 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 172 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0346734181 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 58 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CD8(+) T-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | INTERLEUKIN-12 | - |
dc.subject.keywordPlus | MURINE | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | VACCINATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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