DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Paek, KY | - |
dc.contributor.author | Choi, KB | - |
dc.contributor.author | Kim, TD | - |
dc.contributor.author | Hahm, BS | - |
dc.contributor.author | Kim, KT | - |
dc.contributor.author | Jang, SK | - |
dc.date.accessioned | 2016-03-31T12:56:37Z | - |
dc.date.available | 2016-03-31T12:56:37Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2003-01 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2003-OAK-0000003109 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18752 | - |
dc.description.abstract | The c-myc proto-oncogene plays a key role in the proliferation, differentiation, apoptosis, and regulation of the cell cycle. Recently, it was demonstrated that the 5' nontranslated region (5' NTR) of human c-myc mRNA contains an internal ribosomal entry site (IRES). In this study, we investigated cellular proteins interacting with the IRES element of c-myc mRNA. Heterogeneous nuclear ribonucleoprotein C (hnRNP Q was identified as a cellular protein that interacts specifically with a heptameric U sequence in the c-myc IRES located between two alternative translation initiation codons CUG and AUG. Moreover, the addition of hnRNP C1 in an in vitro translation system enhanced translation of c-myc mRNA. Interestingly, hnRNP C was partially relocalized from the nucleus, where most of the hnRNP C resides at interphase, to the cytoplasm at the G(2)/M phase of the cell cycle. Coincidently, translation mediated through the c-myc IRES was increased at the G(2)/M phase when cap-dependent translation was partially inhibited. On the other hand, a mutant c-myc mRNA lacking the hnRNP C-binding site, showed a decreased level of translation at the G(2)/M phase compared to that of the wild-type message. Taken together, these findings suggest that hmRNP C, via IRES binding, modulates translation of c-myc mRNA in a cell cycle phase-dependent manner. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.title | Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1128/MCB.23.2.708-720.2003 | - |
dc.author.google | Kim, JH | - |
dc.author.google | Paek, KY | - |
dc.author.google | Choi, KB | - |
dc.author.google | Kim, TD | - |
dc.author.google | Hahm, BS | - |
dc.author.google | Kim, KT | - |
dc.author.google | Jang, SK | - |
dc.relation.volume | 23 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 708 | - |
dc.relation.lastpage | 720 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.23, no.2, pp.708 - 720 | - |
dc.identifier.wosid | 000180243500026 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 720 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 708 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.contributor.affiliatedAuthor | Jang, SK | - |
dc.identifier.scopusid | 2-s2.0-0037219006 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 109 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INTERNAL-RIBOSOME-ENTRY | - |
dc.subject.keywordPlus | TRACT-BINDING-PROTEIN | - |
dc.subject.keywordPlus | EUKARYOTIC MESSENGER-RNA | - |
dc.subject.keywordPlus | 5&apos | - |
dc.subject.keywordPlus | NONCODING REGION | - |
dc.subject.keywordPlus | POLIOVIRUS RNA | - |
dc.subject.keywordPlus | VIRUS-RNA | - |
dc.subject.keywordPlus | POLY(RC) BINDING-PROTEIN-2 | - |
dc.subject.keywordPlus | DIFFERENTIAL EXPRESSION | - |
dc.subject.keywordPlus | ALTERNATIVE TRANSLATION | - |
dc.subject.keywordPlus | 5&apos | - |
dc.subject.keywordPlus | -UNTRANSLATED REGION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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