DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ho, MWY | - |
dc.contributor.author | Yang, XN | - |
dc.contributor.author | Carew, MA | - |
dc.contributor.author | Zhang, T | - |
dc.contributor.author | Hua, L | - |
dc.contributor.author | Kwon, YU | - |
dc.contributor.author | Chung, SK | - |
dc.contributor.author | Adelt, S | - |
dc.contributor.author | Vogel, G | - |
dc.contributor.author | Riley, AM | - |
dc.contributor.author | Potter, BVL | - |
dc.contributor.author | Shears, SB | - |
dc.date.accessioned | 2016-03-31T13:08:18Z | - |
dc.date.available | 2016-03-31T13:08:18Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2002-03-19 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.other | 2002-OAK-0000002539 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19154 | - |
dc.description.abstract | Regulation of Cl- channel conductance by Ins(3,4,5,6)P-4 provides receptor-dependent control over salt and fluid secretion [1], cell volume homeostasis [2], and electrical excitability of neurones and smooth muscle [3]. Ignorance of how Ins(3,4,5,6)P4 is synthesized has long hindered our understanding of this signaling pathway. We now show Ins(3,4,5,6)P4 synthesis by Ins(1,3,4,5,6)P,5 1-phosphatase activity by an enzyme previously characterized [4] as an Ins(3,4,5,6)P-4 1-kinase. Rationalization of these phenomena with a ligand binding model unveils Ins(1,3,4)P-3 as not simply an alternative kinase substrate [4, 5], but also an activator of Ins(1,3,4,5,6)P-5 I-phosphatase. Stable overexpression of the enzyme in epithelial monolayers verifies its physiological role in elevating Ins(3,4,5,6)P4 levels and inhibiting secretion. It is exceptional for a single enzyme to catalyze two opposing signaling reactions (1-kinase/1-phosphatase) under physiological conditions. Reciprocal coordination of these opposing reactions offers an alternative to general doctrine that intracellular signals are regulated by integrating multiple, distinct phosphatases and kinases [6]. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CURRENT BIOLOGY | - |
dc.subject | D-MYO-INOSITOL | - |
dc.subject | MYOINOSITOL 3,4,5,6-TETRAKISPHOSPHATE | - |
dc.subject | RAT-LIVER | - |
dc.subject | ENZYME | - |
dc.subject | 1,3,4-TRISPHOSPHATE | - |
dc.subject | TETRAKISPHOSPHATES | - |
dc.subject | HEXAKISPHOSPHATE | - |
dc.subject | 5/6-KINASE | - |
dc.subject | CELLS | - |
dc.title | Regulation of Ins(3,4,5,6)P-4 signaling by a reversible kinase/phosphatase | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1016/S0960-9822(02)00713-3 | - |
dc.author.google | Ho, MWY | - |
dc.author.google | Yang, XN | - |
dc.author.google | Carew, MA | - |
dc.author.google | Zhang, T | - |
dc.author.google | Hua, L | - |
dc.author.google | Kwon, YU | - |
dc.author.google | Chung, SK | - |
dc.author.google | Adelt, S | - |
dc.author.google | Vogel, G | - |
dc.author.google | Riley, AM | - |
dc.author.google | Potter, BVL | - |
dc.author.google | Shears, SB | - |
dc.relation.volume | 12 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 477 | - |
dc.relation.lastpage | 482 | - |
dc.contributor.id | 10200284 | - |
dc.relation.journal | CURRENT BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CURRENT BIOLOGY, v.12, no.6, pp.477 - 482 | - |
dc.identifier.wosid | 000174535700020 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 482 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 477 | - |
dc.citation.title | CURRENT BIOLOGY | - |
dc.citation.volume | 12 | - |
dc.contributor.affiliatedAuthor | Chung, SK | - |
dc.identifier.scopusid | 2-s2.0-0036006292 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 39 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ACTIVATED CHLORIDE CONDUCTANCE | - |
dc.subject.keywordPlus | DEPENDENT PROTEIN-KINASE | - |
dc.subject.keywordPlus | INOSITOL HEXAKISPHOSPHATE | - |
dc.subject.keywordPlus | RAT-LIVER | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | TETRAKISPHOSPHATES | - |
dc.subject.keywordPlus | CHANNEL | - |
dc.subject.keywordPlus | CELL | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
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