DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, DW | - |
dc.contributor.author | Bae, YS | - |
dc.contributor.author | Nam, JO | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Lee, YG | - |
dc.contributor.author | Park, YK | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Baek, SH | - |
dc.date.accessioned | 2016-03-31T13:09:15Z | - |
dc.date.available | 2016-03-31T13:09:15Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2002-03 | - |
dc.identifier.issn | 0026-895X | - |
dc.identifier.other | 2002-OAK-0000002489 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19189 | - |
dc.description.abstract | Prostaglandins (PGs) are known to play a key role in the initiation of labor, but the mechanisms regulating their synthesis in amnion are largely unknown. In this study, the regulatory mechanisms for PGE(2) production during phospholipase D (PLD) and p38-dependent activation of WISH cells were investigated. We found that the stimulation of WISH cells with interleukin (IL)-1beta elicited dose-dependent synthesis of cyclooxygenase-2 (COX-2) mRNA, protein, and their products, PGE(2). Moreover, the treatment of [H-3]myristate-labeled cells in the presence of 1-butanol caused the dose-dependent formation of [H-3]phosphatidylbutanol (PBt), a product specific to PLD activity. Pre-treating the cells with 1-butanol and Ro 31-8220 inhibited the IL-1beta-induced COX-2 expression, but 3-butanol did not affect this response. In addition, evidence that PLD was involved in the stimulation of COX-2 expression was provided by the observations that COX-2 expression was stimulated by the dioctanoyl phosphatidic acid (PA) and that the prevention of PA dephosphorylation by 1-propranolol potentiated COX-2 expression by IL-1beta. Moreover, IL-1beta stimulation of the cells caused the phosphorylation of p38 and extracellular signal-regulated kinase (ERK), and IL-1beta-induced COX-2 expression was inhibited by the pretreatment of WISH cells with a p38 inhibitor, in contrast ERK upstream inhibitor had no effect. Furthermore, Ro 31-8220 inhibited IL-1beta-induced p38 phosphorylation but not ERK phosphorylation. The results of this study indicate that in human amnion cells, IL-1beta might activate PLD through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC PHARMACOLOGY EXPERIMENTAL TH | - |
dc.relation.isPartOf | MOLECULAR PHARMACOLOGY | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | EPIDERMAL GROWTH-FACTOR | - |
dc.subject | PROSTAGLANDIN E-2 | - |
dc.subject | SPONTANEOUS LABOR | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | PHORBOL ESTER | - |
dc.subject | INTERLEUKIN-1-BETA | - |
dc.subject | INVOLVEMENT | - |
dc.subject | ACTIVATION | - |
dc.subject | TERM | - |
dc.title | Regulation of cyclooxygenase-2 expression by phospholipase D in human amnion-derived WISH cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1124/mol.61.3.614 | - |
dc.author.google | Park, DW | - |
dc.author.google | Bae, YS | - |
dc.author.google | Nam, JO | - |
dc.author.google | Kim, JH | - |
dc.author.google | Lee, YG | - |
dc.author.google | Park, YK | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Baek, SH | - |
dc.relation.volume | 61 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 614 | - |
dc.relation.lastpage | 619 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | MOLECULAR PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR PHARMACOLOGY, v.61, no.3, pp.614 - 619 | - |
dc.identifier.wosid | 000174058200017 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 619 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 614 | - |
dc.citation.title | MOLECULAR PHARMACOLOGY | - |
dc.citation.volume | 61 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-0036178938 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 12 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | EPIDERMAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | PROSTAGLANDIN E-2 | - |
dc.subject.keywordPlus | SPONTANEOUS LABOR | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | PHORBOL ESTER | - |
dc.subject.keywordPlus | INTERLEUKIN-1-BETA | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TERM | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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