DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Hwang, JI | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Donowitz, M | - |
dc.contributor.author | Kim, JH | - |
dc.date.accessioned | 2016-03-31T13:13:09Z | - |
dc.date.available | 2016-03-31T13:13:09Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2001-10-19 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2001-OAK-0000002290 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19334 | - |
dc.description.abstract | Mammalian phospholipase C-beta isozymes are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Recent reports suggest that PDZ domain proteins play a significant role of PDZ-containing proteins in the regulation of mammalian PLC-beta isozymes. PDZ-containing proteins mediate the clustering of receptors and signaling molecules and thereby regulate agonist-induced signal transduction in polarized cells such as neuronal and epithelial cells. NORPA, a Drosophila PLC-beta, is known to be a component of a signaling complex that includes TRP and rhodopsin through interaction with DIAD, a PDZ-containing protein. Mammalian PLC-beta1 and -beta2 isoforms interact with a PDZ-containing protein NHERF which is coupled to Trp4, a Ca2+ channel. In addition, PLC-beta3 specifically interacts with E3KARP, another protein closely related to NHERF, through its C-terminal PDZ-binding motif. E3KARP up-regulates the PLC-beta3 activation coupled to muscarinic receptor. In this review, the role of signaling complexes mediated by PDZ-containing proteins in the regulation of PLC-beta isoforms will be discussed. (C) 2001 Academic Press. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | G-protein-coupled receptor | - |
dc.subject | INAD | - |
dc.subject | NHERF | - |
dc.subject | E3KARP | - |
dc.subject | PDZ domain | - |
dc.subject | phospholipase C-beta (PLC-beta) | - |
dc.subject | Trp | - |
dc.subject | PHOSPHOLIPASE-C ISOZYMES | - |
dc.subject | EXCHANGER REGULATORY FACTOR | - |
dc.subject | KINASE-A | - |
dc.subject | BETA(2)-ADRENERGIC RECEPTOR | - |
dc.subject | DOMAIN INTERACTION | - |
dc.subject | SHANK FAMILY | - |
dc.subject | ASSOCIATION | - |
dc.subject | INAD | - |
dc.subject | ACTIVATION | - |
dc.subject | DROSOPHILA | - |
dc.title | Breakthroughs and views - The roles of PDZ-containing proteins in PLC-beta-mediated signaling | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1006/bbrc.2001.5710 | - |
dc.author.google | Suh, PG | - |
dc.author.google | Hwang, JI | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Donowitz, M | - |
dc.author.google | Kim, JH | - |
dc.relation.volume | 288 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 1 | - |
dc.relation.lastpage | 7 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.288, no.1, pp.1 - 7 | - |
dc.identifier.wosid | 000171813400001 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 288 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-0035913998 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 66 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C ISOZYMES | - |
dc.subject.keywordPlus | EXCHANGER REGULATORY FACTOR | - |
dc.subject.keywordPlus | KINASE-A | - |
dc.subject.keywordPlus | BETA(2)-ADRENERGIC RECEPTOR | - |
dc.subject.keywordPlus | DOMAIN INTERACTION | - |
dc.subject.keywordPlus | SHANK FAMILY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | INAD | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordAuthor | G-protein-coupled receptor | - |
dc.subject.keywordAuthor | INAD | - |
dc.subject.keywordAuthor | NHERF | - |
dc.subject.keywordAuthor | E3KARP | - |
dc.subject.keywordAuthor | PDZ domain | - |
dc.subject.keywordAuthor | phospholipase C-beta (PLC-beta) | - |
dc.subject.keywordAuthor | Trp | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.