DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Lee, H | - |
dc.contributor.author | Jun, DJ | - |
dc.contributor.author | Chun, JS | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:15:04Z | - |
dc.date.available | 2016-03-31T13:15:04Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2001-08-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2001-OAK-0000002186 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19406 | - |
dc.description.abstract | Histamine, through H-2 receptors, triggers a prominent rise in intracellular free Ca2+ concentration ([Ca2+](i)) in addition to an elevation of cAMP level in HL-60 promyelocytes. Here we show that the histamine-induced [Ca2+](i) rise was due to influx of Ca2+ from the extracellular space, probably through nonselective cation channels, as incubation of the cells with SKF 96365 abolished the histamine-induced [Ca2+](i) rise, Na+ influx, and membrane depolarization. The Ca2+ influx was specifically inhibited by pretreatment of the cells with PMA or extracellular ATP with 50% inhibitory concentrations of 0.12 +/- 0.03 nM and 185 +/- 17 muM, respectively. Western blot analysis of protein kinase C (PKC) isoforms revealed that PMA (less than or equal to1 nM) and ATP (300 muM) caused selective translocation of PKC-delta to the particulate/membrane fraction. Costimulation of the cells with histamine and SKF 96365 partially reduced histamine-induced granulocytic differentiation, which was evaluated by looking at the extent of fmet-Leu-Phe-induced [Ca2+](i) rise and superoxide generation. In conclusion, nonselective cation channels are opened by stimulation of the H-2 receptor, and the channels are at least in part involved in the induction of histamine-mediated differentiation processes. Both effects of histamine were selectively inhibited probably by the delta isoform of PKC in HL-60 cells. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | DIFFERENTIATED HL-60 CELLS | - |
dc.subject | INCREASES CYTOSOLIC CA2+ | - |
dc.subject | LEUKEMIA-CELLS | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | PHOSPHOLIPASE-C | - |
dc.subject | PC12 CELLS | - |
dc.subject | MAST-CELLS | - |
dc.subject | ATP | - |
dc.subject | CALCIUM | - |
dc.subject | RELEASE | - |
dc.title | Inhibition of H-2 histamine receptor-mediated cation channel opening by protein kinase C in human promyelocytic cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.167.3.1663 | - |
dc.author.google | Suh, BC | - |
dc.author.google | Lee, H | - |
dc.author.google | Jun, DJ | - |
dc.author.google | Chun, JS | - |
dc.author.google | Lee, JH | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 167 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 1663 | - |
dc.relation.lastpage | 1671 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.167, no.3, pp.1663 - 1671 | - |
dc.identifier.wosid | 000170949400065 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1671 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1663 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 167 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0035413352 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 6 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DIFFERENTIATED HL-60 CELLS | - |
dc.subject.keywordPlus | INCREASES CYTOSOLIC CA2+ | - |
dc.subject.keywordPlus | LEUKEMIA-CELLS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | ATP | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | RELEASE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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