Cloning and characterization of 5 '-upstream region of human phospholipase C-beta 2 gene
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- Title
- Cloning and characterization of 5 '-upstream region of human phospholipase C-beta 2 gene
- Authors
- Yun, ES; Lee, SJ; Kim, MJ; Ryu, SH; Suh, PG
- Date Issued
- 2001-06-30
- Publisher
- KOREAN SOC MED BIOCHEMISTRY MOLECULAR
- Abstract
- 5 ' -upstream region of the phospholipase C-beta2 gene, 810 bp, was cloned and characterized. S1 nuclease mapping and primer extension analyses revealed that a single transcriptional start site locates at 284 nucleotides upstream from the beginning of translation. The 5 ' -upstream region lacks both TATA motif and typical initiator sequence, but retains CC-rich segment. Two putative regulatory regions, a negative region (-636/-588) and a positive region (-98/-13) were identified in the upstream region of PLC-beta2 gene. We suggest that the transcription of PLC-beta2 may be regulated by binding of regulatory proteins to the negative and/or positive regulatory regions located in the upstream of the gene.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19477
- DOI
- 10.1038/emm.2001.14
- ISSN
- 1226-3613
- Article Type
- Article
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, vol. 33, no. 2, page. 76 - 82, 2001-06-30
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