DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, SH | - |
dc.contributor.author | Choi, SY | - |
dc.contributor.author | Kim, KT | - |
dc.contributor.author | Lee, CO | - |
dc.date.accessioned | 2016-03-31T13:17:38Z | - |
dc.date.available | 2016-03-31T13:17:38Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2001-07 | - |
dc.identifier.issn | 0160-2446 | - |
dc.identifier.other | 2001-OAK-0000002052 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19502 | - |
dc.description.abstract | Polychlorinated biphenyls (PCBs) have been known as serious environmental pollutants, causing developmental delays, motor dysfunction, and decrease in brain dopamine level in humans and animals. We have investigated the effects of a PCB congener, 2,2 ' ,6-trichlorobiphenyl (PCB 19) on contractile force, Ca2+ transient, and L-type Ca2+ current (I-Ca,I-L) in guinea pig ventricular myocytes stimulated at a rate of 0.25-0.33 Hz. PCB 19 decreased contractile force in a concentration-dependent manner. During the negative inotropic response, the action potential duration at 20% (APD(90)), 90% of repolarization (APD(90)), and the action potential amplitude (APA) were decreased concentration dependently: 30 muM PCB 19 reduced APD(20), APD(90), and APA by 36.7 +/- 3.5%, 22.6 +/- 3.9%, and 2.4 +/- 0.6%, respectively (n = 11, p < 0.01). PCB 19 30 muM decreased the Ca2+ transient and the I-Ca,I-L by 46.8 +/- 1.8% (n = 9, p < 0.01) and 47.1 +/- 3.1% (n = 9, p < 0.01), respectively. The results suggest that PCB 19 decreased the Ca2+ transient through inhibition of L-type Ca2+ channels and that the decreased Ca2+ transient consequently caused a negative inotropic effect in cardiac myocytes. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.isPartOf | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | - |
dc.subject | polychlorinated biphenyl | - |
dc.subject | contractile force | - |
dc.subject | intracellular Ca2+ concentration | - |
dc.subject | L-type Ca2+ current | - |
dc.subject | heart cells | - |
dc.subject | CEREBELLAR GRANULE CELLS | - |
dc.subject | CALCIUM-RELEASE | - |
dc.subject | SARCOPLASMIC-RETICULUM | - |
dc.subject | VENTRICULAR MYOCYTES | - |
dc.subject | VOLTAGE-DEPENDENCE | - |
dc.subject | RAT-BRAIN | - |
dc.subject | CONGENERS | - |
dc.subject | PCBS | - |
dc.subject | NEUROTOXICITY | - |
dc.subject | AROCLOR-1242 | - |
dc.title | Effects of polychlorinated biphenyl 19 (2,2 ',6-trichlorobiphenyl) on contraction, Ca2+ transient, and Ca2+ current of cardiac myocytes | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1097/00005344-200107000-00002 | - |
dc.author.google | Jo, SH | - |
dc.author.google | Choi, SY | - |
dc.author.google | Kim, KT | - |
dc.author.google | Lee, CO | - |
dc.relation.volume | 38 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 11 | - |
dc.relation.lastpage | 20 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, v.38, no.1, pp.11 - 20 | - |
dc.identifier.wosid | 000169444400002 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 11 | - |
dc.citation.title | JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | - |
dc.citation.volume | 38 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0034946268 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 7 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CEREBELLAR GRANULE CELLS | - |
dc.subject.keywordPlus | CALCIUM-RELEASE | - |
dc.subject.keywordPlus | SARCOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | VENTRICULAR MYOCYTES | - |
dc.subject.keywordPlus | VOLTAGE-DEPENDENCE | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | CONGENERS | - |
dc.subject.keywordPlus | PCBS | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | AROCLOR-1242 | - |
dc.subject.keywordAuthor | polychlorinated biphenyl | - |
dc.subject.keywordAuthor | contractile force | - |
dc.subject.keywordAuthor | intracellular Ca2+ concentration | - |
dc.subject.keywordAuthor | L-type Ca2+ current | - |
dc.subject.keywordAuthor | heart cells | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.