DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, JW | - |
dc.contributor.author | Baek, WK | - |
dc.contributor.author | Yang, SH | - |
dc.contributor.author | Chang, J | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Suh, MH | - |
dc.date.accessioned | 2016-03-31T13:22:34Z | - |
dc.date.available | 2016-03-31T13:22:34Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2001-02-05 | - |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.other | 2001-OAK-0000001787 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19685 | - |
dc.description.abstract | It has been recognized that the HCV (hepatitis C virus) core protein plays an important role in hepatocarcinogenesis. The functional inactivation of the Rb pathway appears to be a major event for multi-step cancer carcinogenesis. To elucidate the role of the HCV core protein in hepatocarcinogenesis, we investigated the effect of the HCV core protein on the Rb pathway in both Rat-1 cell lines, stably expressing the HCV core protein and the doxycycline-regulated cell lines. The HCV core stable transfectants showed a dramatic decrease ill the pRb levels and E2F-1 up-regulation. In the doxycycline-regulated cell lines, the PRb levels were significantly decreased which are followed by E2F-1 up-regulation. HCV core stable transfectants showed higher cell growth rates and were sensitize to apoptosis. Thus, our results first indicate that the HCV core protein decreases the expression of pRb, thereby allowing E2F-1 to be constitutively active, which is thought to result in rapid cell proliferation or sensitizing to apoptosis. (C) 2001 Elsevier Science B.V. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.subject | hepatitis C virus | - |
dc.subject | core protein | - |
dc.subject | hepatocarcinogenesis | - |
dc.subject | Rb pathway | - |
dc.subject | C VIRUS CORE | - |
dc.subject | RAT EMBRYO FIBROBLASTS | - |
dc.subject | CELL-CYCLE CONTROL | - |
dc.subject | RETINOBLASTOMA PROTEIN | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | APOPTOSIS | - |
dc.subject | SUPPRESSION | - |
dc.subject | CANCER | - |
dc.title | HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0167-4889(00)00137-3 | - |
dc.author.google | Cho, JW | - |
dc.author.google | Baek, WK | - |
dc.author.google | Yang, SH | - |
dc.author.google | Chang, J | - |
dc.author.google | Sung, YC | - |
dc.author.google | Suh, MH | - |
dc.relation.volume | 1538 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 59 | - |
dc.relation.lastpage | 66 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v.1538, no.1, pp.59 - 66 | - |
dc.identifier.wosid | 000166872700007 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 66 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.citation.volume | 1538 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0035809057 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 48 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | C VIRUS CORE | - |
dc.subject.keywordPlus | RAT EMBRYO FIBROBLASTS | - |
dc.subject.keywordPlus | RETINOBLASTOMA PROTEIN | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | core protein | - |
dc.subject.keywordAuthor | hepatocarcinogenesis | - |
dc.subject.keywordAuthor | Rb pathway | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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