DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kong, YY | - |
dc.contributor.author | Penninger, JM | - |
dc.date.accessioned | 2016-03-31T13:24:37Z | - |
dc.date.available | 2016-03-31T13:24:37Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2000-10 | - |
dc.identifier.issn | 0531-5565 | - |
dc.identifier.other | 2000-OAK-0000001678 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19762 | - |
dc.description.abstract | Osteoprotegerin ligand (OPGL, TNFS11) and its receptor RANK (TNFRS11A) are essential for the development and activation of osteoclasts and critical regulators of physiological bone remodeling and osteoporosis. Production of OPGL by activated T cells can directly regulate osteoclastogenesis and bone remodeling. This may explain why autoimmune diseases, cancers, leukemias, asthma and chronic viral infections such as hepatitis and HIV result in systemic and local bone loss. OPGL is also the pathogenetic factor that causes bone and cartilage destruction and clinical crippling in arthritis. Inhibition of OPGL binding to RANK via the natural decoy receptor osteoprotegerin (OPG) prevents bone loss in postmenopausal osteoporosis and cancer metastases and completely blocks crippling in a rat model of arthritis. Moreover, OPG expression is induced by estrogen which provides a molecular explanation of postmenopausal osteoporosis in women. (C) 2000 Elsevier Science Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | EXPERIMENTAL GERONTOLOGY | - |
dc.subject | bone remodeling | - |
dc.subject | osteoporosis | - |
dc.subject | osteoprotegerin ligand | - |
dc.subject | OSTEOCLASTOGENESIS-INHIBITORY FACTOR | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | OSTEOPROTEGERIN MESSENGER-RNA | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | T-CELLS | - |
dc.subject | DIFFERENTIATION FACTOR | - |
dc.subject | LIGAND | - |
dc.subject | RECEPTOR | - |
dc.subject | TRANCE | - |
dc.subject | FAMILY | - |
dc.title | Molecular control of bone remodeling and osteoporosis | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0531-5565(00)00178-9 | - |
dc.author.google | Kong, YY | - |
dc.author.google | Penninger, JM | - |
dc.relation.volume | 35 | - |
dc.relation.issue | 8 | - |
dc.relation.startpage | 947 | - |
dc.relation.lastpage | 956 | - |
dc.relation.journal | EXPERIMENTAL GERONTOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL GERONTOLOGY, v.35, no.8, pp.947 - 956 | - |
dc.identifier.wosid | 000165680400005 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 956 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 947 | - |
dc.citation.title | EXPERIMENTAL GERONTOLOGY | - |
dc.citation.volume | 35 | - |
dc.contributor.affiliatedAuthor | Kong, YY | - |
dc.identifier.scopusid | 2-s2.0-0033739271 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 61 | - |
dc.type.docType | Review | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | OSTEOCLASTOGENESIS-INHIBITORY FACTOR | - |
dc.subject.keywordPlus | TNF FAMILY-MEMBER | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | OSTEOPROTEGERIN MESSENGER-RNA | - |
dc.subject.keywordPlus | FACTOR RECEPTOR FAMILY | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | DIFFERENTIATION FACTOR | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | TRANCE | - |
dc.subject.keywordAuthor | bone remodeling | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | osteoprotegerin ligand | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
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