DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Kim, TD | - |
dc.contributor.author | Lee, IS | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:26:42Z | - |
dc.date.available | 2016-03-31T13:26:42Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2000-10 | - |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.other | 2000-OAK-0000001567 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19840 | - |
dc.description.abstract | 1 The regulatory mode of the P2Y(11) purinoceptor-mediated signalling cascades towards phospholipase C and adenylyl cyclase was studied in HL-60 promyelocytes. 2 Treatment with the potent P2Y(11) receptor activator dATP evoked an elevated intracellular Ca2+ concentration ([Ca2+],) and inositol 1,4,5-trisphosphate (IP3) production that was sustained for longer than 30 min. However, the dATP-induced responses were significantly inhibited by the activation of protein kinase C after a short exposure to phorbol 12-myristate 13-acetate (PMA). 3 dATP also potently stimulated cyclic AMP production with half maximum effect seen at 23 +/- 7 mu M dATP. In addition, a 5-min pretreatment with PMA enhanced the dATP-stimulated cyclic AMP accumulation. 4 PMA potentiated the cyclic AMP production when adenylyl cyclase was activated directly by forskolin or indirectly by G protein activation after cholera toxin treatment. dATP also enhanced the forskolin-mediated cyclic AMP generation. 5 Treatment of the cells with 10 mu M U-73122, which almost completely blocked the dATP-stimulated IF, production and [Ca2+](i) rise, had no effect on cyclic AMP accumulation, while 10 mu M 9-(tetrahydro-2-furyl)adenine (SQ 22536), which inhibited the adenylyl cyclase activation; did not effect the dATP-stimulated phosphoinositide turnover. 6 Taken together, the results indicate that P2Y(11) receptor-mediated activation of phospholipase C and adenylyl cyclase occurs through independent pathways and is differentially regulated by protein kinase C in HL-60 cells. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | BRITISH JOURNAL OF PHARMACOLOGY | - |
dc.subject | human HL-60 promyelocytic leukaemic cells | - |
dc.subject | P2Y(11) receptor | - |
dc.subject | dATP | - |
dc.subject | UTP | - |
dc.subject | phospholipase C | - |
dc.subject | adenylyl cyclase | - |
dc.subject | AORTIC ENDOTHELIAL-CELLS | - |
dc.subject | GLAND TUMOR-CELLS | - |
dc.subject | PHORBOL-ESTER | - |
dc.subject | PHARMACOLOGICAL CHARACTERIZATION | - |
dc.subject | INOSITOL 1,4,5-TRISPHOSPHATE | - |
dc.subject | NUCLEOTIDE RECEPTORS | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | MOLECULAR-CLONING | - |
dc.subject | LEUKEMIA-CELLS | - |
dc.subject | ATP | - |
dc.title | Differential regulation of P2Y(11) receptor-mediated signalling to phospholipase C and adenylyl cyclase by protein kinase C in HL-60 promyelocytes | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/sj.bjp.0703581 | - |
dc.author.google | Suh, BC | - |
dc.author.google | Kim, TD | - |
dc.author.google | Lee, IS | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 131 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 489 | - |
dc.relation.lastpage | 497 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | BRITISH JOURNAL OF PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF PHARMACOLOGY, v.131, no.3, pp.489 - 497 | - |
dc.identifier.wosid | 000089716100014 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 497 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 489 | - |
dc.citation.title | BRITISH JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 131 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0033776537 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | AORTIC ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | GLAND TUMOR-CELLS | - |
dc.subject.keywordPlus | PHORBOL-ESTER | - |
dc.subject.keywordPlus | PHARMACOLOGICAL CHARACTERIZATION | - |
dc.subject.keywordPlus | INOSITOL 1,4,5-TRISPHOSPHATE | - |
dc.subject.keywordPlus | NUCLEOTIDE RECEPTORS | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | MOLECULAR-CLONING | - |
dc.subject.keywordPlus | LEUKEMIA-CELLS | - |
dc.subject.keywordPlus | ATP | - |
dc.subject.keywordAuthor | human HL-60 promyelocytic leukaemic cells | - |
dc.subject.keywordAuthor | P2Y(11) receptor | - |
dc.subject.keywordAuthor | dATP | - |
dc.subject.keywordAuthor | UTP | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | adenylyl cyclase | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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