DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fata, JE | - |
dc.contributor.author | Kong, YY | - |
dc.contributor.author | Li, J | - |
dc.contributor.author | Sasaki, T | - |
dc.contributor.author | Irie-Sasaki, J | - |
dc.contributor.author | Moorehead, RA | - |
dc.contributor.author | Elliott, R | - |
dc.contributor.author | Scully, S | - |
dc.contributor.author | Voura, EB | - |
dc.contributor.author | Lacey, DL | - |
dc.contributor.author | Boyle, WJ | - |
dc.contributor.author | Khokha, R | - |
dc.contributor.author | Penninger, JM | - |
dc.date.accessioned | 2016-03-31T13:26:43Z | - |
dc.date.available | 2016-03-31T13:26:43Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2000-09-29 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.other | 2000-OAK-0000001566 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19841 | - |
dc.description.abstract | Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling. We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Transplantation and OPGL-rescue experiments in opgl(-/-) and rank(-/-) pregnant females showed that OPGL acts directly on RANK-expressing mammary epithelial cells. The effects of OPGL are autonomous to epithelial cells. The mammary gland defect in female opgl(-/-) mice is characterized by enhanced apoptosis and failures in proliferation and PKB activation in lobulo-alveolar buds that can be reversed by recombinant OPGL treatment. These data provide a novel paradigm in mammary gland development and an evolutionary rationale for hormonal regulation and gender bias of osteoporosis in females. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CELL | - |
dc.subject | T-CELLS | - |
dc.subject | RECEPTOR | - |
dc.subject | MICE | - |
dc.subject | PROLACTIN | - |
dc.subject | PREGNANCY | - |
dc.subject | LACTATION | - |
dc.subject | PROTEIN | - |
dc.subject | MOUSE | - |
dc.title | The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0092-8674(00)00103-3 | - |
dc.author.google | Fata, JE | - |
dc.author.google | Kong, YY | - |
dc.author.google | Li, J | - |
dc.author.google | Sasaki, T | - |
dc.author.google | Irie-Sasaki, J | - |
dc.author.google | Moorehead, RA | - |
dc.author.google | Elliott, R | - |
dc.author.google | Scully, S | - |
dc.author.google | Voura, E | - |
dc.relation.volume | 103 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 41 | - |
dc.relation.lastpage | 50 | - |
dc.relation.journal | CELL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELL, v.103, no.1, pp.41 - 50 | - |
dc.identifier.wosid | 000089636400007 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 103 | - |
dc.contributor.affiliatedAuthor | Kong, YY | - |
dc.identifier.scopusid | 2-s2.0-0034730327 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 465 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PROLACTIN | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | LACTATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MOUSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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