DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, SK | - |
dc.contributor.author | Lee, KW | - |
dc.contributor.author | Kang, HI | - |
dc.contributor.author | Yamashita, C | - |
dc.contributor.author | Kudo, M | - |
dc.contributor.author | Yoshida, Y | - |
dc.date.accessioned | 2016-03-31T13:26:45Z | - |
dc.date.available | 2016-03-31T13:26:45Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2000-10 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | 2000-OAK-0000001564 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19842 | - |
dc.description.abstract | A series of azolylmethyloxolane derivatives with modified sterol side-chain structures, designed as potential dual functional inhibitors of cytochrome P450 14 alpha-demethylase (14DM) and Delta(24)-sterol methyltransferase (24-SMT) based on the common characteristic features of 24-aminosterols and azole antifungal agents, were synthesized and evaluated for their antifungal activities and inhibitory activities of 14DM and 24-SMT. Among these compounds, imidazolylmethyloxolane derivatives 28a and 28b showed potent in vitro antifungal activities comparable to those of itraconazole. However, the in vitro bioactivities have not been linearly translated into in vivo protection data for some unknown reasons. (C) 2000 Elsevier Science Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.subject | SODIUM-BOROHYDRIDE | - |
dc.subject | SACCHAROMYCES-CEREVISIAE | - |
dc.subject | METHYL TRANSFERASE | - |
dc.subject | AZOLE DERIVATIVES | - |
dc.subject | REDUCTION | - |
dc.subject | CHLORIDE | - |
dc.subject | OXIMES | - |
dc.subject | STEROL | - |
dc.subject | AMINE | - |
dc.subject | RING | - |
dc.title | Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1016/S0968-0896(00)00177-2 | - |
dc.author.google | Chung, SK | - |
dc.author.google | Lee, KW | - |
dc.author.google | Kang, HI | - |
dc.author.google | Yamashita, C | - |
dc.author.google | Kudo, M | - |
dc.author.google | Yoshida, Y | - |
dc.relation.volume | 8 | - |
dc.relation.issue | 10 | - |
dc.relation.startpage | 2475 | - |
dc.relation.lastpage | 2486 | - |
dc.contributor.id | 10200284 | - |
dc.relation.journal | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.8, no.10, pp.2475 - 2486 | - |
dc.identifier.wosid | 000089624800011 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2486 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2475 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Chung, SK | - |
dc.identifier.scopusid | 2-s2.0-0033821775 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SODIUM-BOROHYDRIDE | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | METHYL TRANSFERASE | - |
dc.subject.keywordPlus | AZOLE DERIVATIVES | - |
dc.subject.keywordPlus | REDUCTION | - |
dc.subject.keywordPlus | CHLORIDE | - |
dc.subject.keywordPlus | OXIMES | - |
dc.subject.keywordPlus | STEROL | - |
dc.subject.keywordPlus | AMINE | - |
dc.subject.keywordPlus | RING | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
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