DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, IS | - |
dc.contributor.author | Park, TJ | - |
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Rhee, IJ | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:39:20Z | - |
dc.date.available | 2016-03-31T13:39:20Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1999-09-15 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.other | 1999-OAK-0000000879 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20310 | - |
dc.description.abstract | We investigated the effect of chlorpromazine (CPZ), a phenothiazine neuroleptic, on catecholamine secretion in rat pheochromocytoma (PC12) cells. CPZ inhibited [H-3]norepinephrine ([H-3]NE) secretion induced by 1,1 dimethyl-4-phenylpiperazinium iodide (DMPP), an agonist of nicotinic acetylcholine receptors (nAChRs) with an IC50 value of 1.0 +/- 0.2 mu M. The DMPP-induced rise in cytosolic free Ca2+ concentration [Ca2+], was inhibited by CPZ with an IC50 of 1.9 +/- 0.1 mu M. The DMPP induced increase in cytosolic free Nat concentration [Na+], was also inhibited by CPZ with a similar potency. Furthermore, the binding of [H-3]nicotine to PC12 cells was inhibited by CPZ with an IC50 value of 2.7 +/- 0.6 mu M, suggesting that the nAChRs themselves are inhibited by CPZ. In addition, both 70 mM K+-induced [H-3]NE secretion and [Ca2+](i) increase were inhibited by CPZ with IC50 of 7.9 +/- 1.1 and 6.2 +/- 0.3 mu M, respectively. Experiments with Ca2+ channel antagonists suggest that L-type Ca2+ channels are mainly responsible for the inhibition. We conclude that CPZ inhibits catecholamine secretion by blocking nAChRs and L-type Ca2+ channels, with the former being more sensitive to CPZ. (C) 1999 Elsevier Science Inc. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.subject | chlorpromazine | - |
dc.subject | catecholamine secretion | - |
dc.subject | nicotinic receptor | - |
dc.subject | L-type Ca2+ channels | - |
dc.subject | PC12 cells | - |
dc.subject | SENSITIVE CALCIUM CHANNELS | - |
dc.subject | ADRENAL CHROMAFFIN CELLS | - |
dc.subject | PC12 CELLS | - |
dc.subject | ACETYLCHOLINE-RECEPTOR | - |
dc.subject | H-3 CHLORPROMAZINE | - |
dc.subject | POTASSIUM CURRENTS | - |
dc.subject | BINDING-SITES | - |
dc.subject | RELEASE | - |
dc.subject | SODIUM | - |
dc.subject | DRUGS | - |
dc.title | Chlorpromazine-induced inhibition of catecholamine secretion by a differential blockade of nicotinic receptors and L-type Ca2+ channels in rat pheochromocytoma cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0006-2952(99)00181-1 | - |
dc.author.google | Lee, IS | - |
dc.author.google | Park, TJ | - |
dc.author.google | Suh, BC | - |
dc.author.google | Kim, YS | - |
dc.author.google | Rhee, IJ | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 58 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 1017 | - |
dc.relation.lastpage | 1024 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | BIOCHEMICAL PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.58, no.6, pp.1017 - 1024 | - |
dc.identifier.wosid | 000082039500012 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1024 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1017 | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 58 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0032798014 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 18 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SENSITIVE CALCIUM CHANNELS | - |
dc.subject.keywordPlus | ADRENAL CHROMAFFIN CELLS | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | ACETYLCHOLINE-RECEPTOR | - |
dc.subject.keywordPlus | H-3 CHLORPROMAZINE | - |
dc.subject.keywordPlus | POTASSIUM CURRENTS | - |
dc.subject.keywordPlus | BINDING-SITES | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | SODIUM | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordAuthor | chlorpromazine | - |
dc.subject.keywordAuthor | catecholamine secretion | - |
dc.subject.keywordAuthor | nicotinic receptor | - |
dc.subject.keywordAuthor | L-type Ca2+ channels | - |
dc.subject.keywordAuthor | PC12 cells | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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