DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, CH | - |
dc.contributor.author | Oh, JI | - |
dc.contributor.author | Park, HD | - |
dc.contributor.author | Kim, HJ | - |
dc.contributor.author | Park, TK | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Hong, CY | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Ahn, KH | - |
dc.contributor.author | Kim, YZ | - |
dc.date.accessioned | 2016-03-31T13:42:51Z | - |
dc.date.available | 2016-03-31T13:42:51Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 1999-04 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.other | 1999-OAK-0000000701 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20438 | - |
dc.description.abstract | LB50016 was characterized as a selective and potent 5-MT1A receptor agonist and evaluate its anxiolytic and antidepressant activities. It shows high affinity for 5-HT1A receptor, moderate affinity for alpha(2) adrenergic and 5-HT2A receptors and no significant affinity for other receptors tested. Hypothermia and increased serum corticosterone level were observed in LB50016-treated rats, which are mediated mostly by post synaptic 5-HT1A receptor activation. In the mouse forced swim model for depression, LB50016-elicited dose-dependent reductions in immobility time, showing ED50 of approximately 3 mg/kg i.p., which was blocked by pretreatment of NAN-190, 5-HT1A antagonist. In face-to-face test for anxiolytic activity in mice, estimated ED50 was 2 mg/kg, i.p.. In isolation-induced aggression test with mice, fifty-fold increases in latency to attack were observed at 30 min and last up to 4 h after LB50016 treatment (3 mg/kg, i.p.). Taken together, LB50016-induced pharmacological activities are mediated by activation of 5-HT1A receptors, offering an effective therapeutic candidate in the management of anxiety and depression in humans. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.subject | 5-HT1A receptors | - |
dc.subject | anxiolytic | - |
dc.subject | antidepressant | - |
dc.subject | LB50016 | - |
dc.subject | pyrrolidine | - |
dc.subject | 5-HYDROXYTRYPTAMINE(1A) AGONIST | - |
dc.subject | ANIMAL-MODELS | - |
dc.subject | BINDING-SITES | - |
dc.subject | RAT | - |
dc.subject | ANTAGONIST | - |
dc.subject | HYPOTHERMIA | - |
dc.subject | DEPRESSION | - |
dc.subject | RESPONSES | - |
dc.subject | 8-OH-DPAT | - |
dc.subject | BUSPIRONE | - |
dc.title | Pharmacological characterization of LB50016, N-(4-amino)butyl 3-phenylpyrrolidine derivative, as a new 5-HT1A receptor agonist | - |
dc.type | Article | - |
dc.contributor.college | 분자소재융합계의 전자-광 거동연구센터 | - |
dc.identifier.doi | 10.1007/BF02976540 | - |
dc.author.google | Lee, CH | - |
dc.author.google | Oh, JI | - |
dc.author.google | Park, HD | - |
dc.author.google | Kim, HJ | - |
dc.author.google | Park, TK | - |
dc.author.google | Kim, JS | - |
dc.author.google | Hong, CY | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Ahn, KH | - |
dc.author.google | Kim, YZ | - |
dc.relation.volume | 22 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 157 | - |
dc.relation.lastpage | 164 | - |
dc.contributor.id | 10087916 | - |
dc.relation.journal | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.22, no.2, pp.157 - 164 | - |
dc.identifier.wosid | 000079751000010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 164 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 157 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Ahn, KH | - |
dc.identifier.scopusid | 2-s2.0-0033113583 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | 5-HYDROXYTRYPTAMINE(1A) AGONIST | - |
dc.subject.keywordPlus | ANIMAL-MODELS | - |
dc.subject.keywordPlus | BINDING-SITES | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordPlus | HYPOTHERMIA | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | 8-OH-DPAT | - |
dc.subject.keywordPlus | BUSPIRONE | - |
dc.subject.keywordAuthor | 5-HT1A receptors | - |
dc.subject.keywordAuthor | anxiolytic | - |
dc.subject.keywordAuthor | antidepressant | - |
dc.subject.keywordAuthor | LB50016 | - |
dc.subject.keywordAuthor | pyrrolidine | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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