DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Chae, HD | - |
dc.contributor.author | Chung, JH | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:44:56Z | - |
dc.date.available | 2016-03-31T13:44:56Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1999-01 | - |
dc.identifier.issn | 0007-1188 | - |
dc.identifier.other | 1999-OAK-0000000591 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20514 | - |
dc.description.abstract | 1 The adrenoceptor in a mouse pineal gland tumour cell line (PGT-beta) was identified and characterized using pharmacological and physiological approaches. 2 Adrenaline and noradrenaline, adrenoceptor agonists, stimulated cyclic AMP generation in a concentration-dependent manner, but had no effect on inositol 1,4,5-trisphosphate production. Adrenaline was a more potent activator of cyclic AMP generation than noradrenaline, with half maximal-effective concentrations (EC50) seen at 175 +/- 22 nM and 18 +/- 2 mu M for adrenaline and noradrenaline, respectively. 3 The addition of forskolin synergistically stimulated the adrenaline-mediated cyclic AMP generation in a concentration-dependent manner. 4 The pA(2) value for the specific beta(2)-adrenoceptor antagonist ICI-118,551 (8.7 +/- 0.4) as an antagonist of the adrenaline-stimulated cyclic AMP generation were similar to 3 units higher than the value for the beta(1)-adrenoceptor antagonist atenolol (5.6 +/- 0.3). 5 Treatment of the cells with adrenaline and forskolin evoked a similar to 3 fold increase in the activity of serotonin N-acetyltransferase with the peak occurring 6 h after stimulation. 6 These results suggest the presence of beta(2)-adrenoceptors in mouse pineal cells and a functional relationship between the adenylyl cyclase system and the regulation of N-acetyltransferase expression. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | STOCKTON PRESS | - |
dc.relation.isPartOf | BRITISH JOURNAL OF PHARMACOLOGY | - |
dc.subject | mouse pineal gland cell | - |
dc.subject | beta(2)-adrenoceptor | - |
dc.subject | adrenaline | - |
dc.subject | noradrenaline | - |
dc.subject | serotonin N-acetyltransferase | - |
dc.subject | adenylyl cyclase | - |
dc.subject | SEROTONIN N-ACETYLTRANSFERASE | - |
dc.subject | ADRENERGIC-RECEPTOR | - |
dc.subject | MELATONIN SYNTHESIS | - |
dc.subject | BETA-3-ADRENERGIC RECEPTOR | - |
dc.subject | NOCTURNAL INCREASE | - |
dc.subject | PHOSPHOLIPASE-C | - |
dc.subject | STIMULATION | - |
dc.subject | GENE | - |
dc.subject | BETA(3)-ADRENOCEPTOR | - |
dc.subject | ADRENOCEPTOR | - |
dc.title | Pharmacological characterization of beta(2)-adrenoceptor in PGT-beta mouse pineal gland tumour cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/sj.bjp.0702248 | - |
dc.author.google | Suh, BC | - |
dc.author.google | Chae, HD | - |
dc.author.google | Chung, JH | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 126 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 399 | - |
dc.relation.lastpage | 406 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | BRITISH JOURNAL OF PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF PHARMACOLOGY, v.126, no.2, pp.399 - 406 | - |
dc.identifier.wosid | 000078343600002 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 406 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 399 | - |
dc.citation.title | BRITISH JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 126 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0032587760 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 10 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SEROTONIN N-ACETYLTRANSFERASE | - |
dc.subject.keywordPlus | ADRENERGIC-RECEPTOR | - |
dc.subject.keywordPlus | MELATONIN SYNTHESIS | - |
dc.subject.keywordPlus | BETA-3-ADRENERGIC RECEPTOR | - |
dc.subject.keywordPlus | NOCTURNAL INCREASE | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | BETA(3)-ADRENOCEPTOR | - |
dc.subject.keywordPlus | ADRENOCEPTOR | - |
dc.subject.keywordAuthor | mouse pineal gland cell | - |
dc.subject.keywordAuthor | beta(2)-adrenoceptor | - |
dc.subject.keywordAuthor | adrenaline | - |
dc.subject.keywordAuthor | noradrenaline | - |
dc.subject.keywordAuthor | serotonin N-acetyltransferase | - |
dc.subject.keywordAuthor | adenylyl cyclase | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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