DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Lee, IS | - |
dc.contributor.author | Chae, HD | - |
dc.contributor.author | Han, S | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:54:10Z | - |
dc.date.available | 2016-03-31T13:54:10Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1998-04-30 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 1998-OAK-0000000188 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20797 | - |
dc.description.abstract | Mastoparan, a peptide toxin from wasp venome, mimics receptors by stimulating the GTPase activity of guanine nucleotide binding proteins and the G-protein-coupled phospholipase C (PLC), By using Mas-7, the active analog of mastoparan, we showed that it makes pores in the plasma membrane. Treatment with Mas-7 but not Mas-17, the inactive analog, produced a concentration-dependent rise in intracellular Ca2+ concentration ([Ca2+](i)) and facilitated the uptake of ethidium bromide (EtBr) (314 Da) to a sustained level during the stimulation. In addition, Mas-7 triggered the influx of lucifer yellow (457 Da), while it did not induce the influx of fura-2 (831 Da) and Evans blue (961 Da). However, the Mas-7-induced permeability was selectively prevented by the addition of La3+, Ni2+, and Co2+, but not Cd2+. This blocking activity was concentration-dependent. While the stimulatory effect of Mas-7 on PLC activity was dependent on extracellular Ca2+, the pore forming activity of Mas-7 was not effected by removal of extracellular Ca2+ These results, therefore, suggest that the mastoparan's action in pore formation is independent from its action in PLC stimulation and is negatively effected by inorganic cations. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | human neuroblastoma | - |
dc.subject | lanthanum | - |
dc.subject | mastoparan | - |
dc.subject | phospholipase C | - |
dc.subject | pore formation | - |
dc.subject | SK-N-BE(2)C | - |
dc.subject | GTP-BINDING PROTEINS | - |
dc.subject | WASP VENOM | - |
dc.subject | C ACTIVATION | - |
dc.subject | MASTOPARAN | - |
dc.subject | MEMBRANE | - |
dc.subject | RECEPTOR | - |
dc.subject | EXOCYTOSIS | - |
dc.subject | MECHANISMS | - |
dc.subject | PEPTIDES | - |
dc.subject | KINASE | - |
dc.title | Characterization of Mas-7-induced pore formation in SK-N-BE(2)C human neuroblastoma cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Suh, BC | - |
dc.author.google | Lee, IS | - |
dc.author.google | Chae, HD | - |
dc.author.google | Han, S | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 8 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 162 | - |
dc.relation.lastpage | 168 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.8, no.2, pp.162 - 168 | - |
dc.identifier.wosid | 000073320700006 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 168 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 162 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 8 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0032580051 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 3 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GTP-BINDING PROTEINS | - |
dc.subject.keywordPlus | WASP VENOM | - |
dc.subject.keywordPlus | C ACTIVATION | - |
dc.subject.keywordPlus | MASTOPARAN | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | EXOCYTOSIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | human neuroblastoma | - |
dc.subject.keywordAuthor | lanthanum | - |
dc.subject.keywordAuthor | mastoparan | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | pore formation | - |
dc.subject.keywordAuthor | SK-N-BE(2)C | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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