Article
Cited 50 time in 
Cited 53 time in 
Cited 53 time in
Metadata Downloads
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chang, JS | - |
| dc.contributor.author | Noh, DY | - |
| dc.contributor.author | Park, IA | - |
| dc.contributor.author | Kim, MJ | - |
| dc.contributor.author | Song, H | - |
| dc.contributor.author | Ryu, SH | - |
| dc.contributor.author | Suh, PG | - |
| dc.date.accessioned | 2016-03-31T13:58:39Z | - |
| dc.date.available | 2016-03-31T13:58:39Z | - |
| dc.date.created | 2009-08-12 | - |
| dc.date.issued | 1997-12-15 | - |
| dc.identifier.issn | 0008-5472 | - |
| dc.identifier.other | 1998-OAK-0000000002 | - |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20936 | - |
| dc.description.abstract | Phospholipase C-gamma 1 (PLC-gamma l) mediates signals from various extracellular origins to evoke cellular events such as mitogenesis. Previously, we reported that PLC-gamma 1 was highly expressed in colorectal cancer and familial adenomatous polyposis, suggesting that PLC-gamma 1 might be oncogenic. In this study, we have established rat 3Y1 fibroblasts that overexpress whole PLC-gamma 1 and src homology 2 (SH2)-SH2-SH3 domain of PLC-gamma 1. These cells showed a transformed phenotype and were tumorigenic when transplanted into nude mice. These results indicate that overexpression of PLC-gamma 1 could transform rat fibroblasts, and the transformation is mediated by SH2-SH2-SH3 domain of PLC-gamma 1. | - |
| dc.description.statementofresponsibility | X | - |
| dc.language | English | - |
| dc.publisher | AMER ASSOC CANCER RESEARCH | - |
| dc.relation.isPartOf | CANCER RESEARCH | - |
| dc.subject | ELEVATED CONTENT | - |
| dc.subject | DNA-SYNTHESIS | - |
| dc.subject | CARCINOMAS | - |
| dc.subject | ANTIBODIES | - |
| dc.subject | DOMAIN | - |
| dc.subject | SRC | - |
| dc.title | Overexpression of phospholipase C-gamma 1 in rat 3Y1 fibroblast cells leads to malignant transformation | - |
| dc.type | Article | - |
| dc.contributor.college | 생명과학과 | - |
| dc.author.google | Chang, JS | - |
| dc.author.google | Noh, DY | - |
| dc.author.google | Park, IA | - |
| dc.author.google | Kim, MJ | - |
| dc.author.google | Song, H | - |
| dc.author.google | Ryu, SH | - |
| dc.author.google | Suh, PG | - |
| dc.relation.volume | 57 | - |
| dc.relation.issue | 24 | - |
| dc.relation.startpage | 5465 | - |
| dc.relation.lastpage | 5468 | - |
| dc.contributor.id | 10052640 | - |
| dc.relation.journal | CANCER RESEARCH | - |
| dc.relation.index | SCI급, SCOPUS 등재논문 | - |
| dc.relation.sci | SCI | - |
| dc.collections.name | Journal Papers | - |
| dc.type.rims | ART | - |
| dc.identifier.bibliographicCitation | CANCER RESEARCH, v.57, no.24, pp.5465 - 5468 | - |
| dc.identifier.wosid | 000070948600007 | - |
| dc.date.tcdate | 2019-01-01 | - |
| dc.citation.endPage | 5468 | - |
| dc.citation.number | 24 | - |
| dc.citation.startPage | 5465 | - |
| dc.citation.title | CANCER RESEARCH | - |
| dc.citation.volume | 57 | - |
| dc.contributor.affiliatedAuthor | Ryu, SH | - |
| dc.contributor.affiliatedAuthor | Suh, PG | - |
| dc.identifier.scopusid | 2-s2.0-15644368498 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalClass | 1 | - |
| dc.description.wostc | 48 | - |
| dc.type.docType | Article | - |
| dc.subject.keywordPlus | ELEVATED CONTENT | - |
| dc.subject.keywordPlus | DNA-SYNTHESIS | - |
| dc.subject.keywordPlus | CARCINOMAS | - |
| dc.subject.keywordPlus | ANTIBODIES | - |
| dc.subject.keywordPlus | DOMAIN | - |
| dc.subject.keywordPlus | SRC | - |
| dc.relation.journalWebOfScienceCategory | Oncology | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Oncology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Communities & Collection
Related Researcher
- 류성호RYU, SUNG HO
- Dept of Life Sciences