DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, H | - |
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T14:09:10Z | - |
dc.date.available | 2016-03-31T14:09:10Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1997-08-29 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.other | 1997-OAK-0000009879 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21242 | - |
dc.description.abstract | Extracellular ATP increases intracellular Ca2+ ([Ca2+](i)) in HL-60 cells. When cells are stimulated with supramaximal concentrations of ATP, although the initial [Ca2+](i) increase is similar over a range of 30, 100, and 300 mu M ATP, the rate of the return to basal [Ca2+](i) level is faster in cells treated with higher concentrations of ATP, This probably results from differences in Ca2+ influx rather than Ca2+ release, since the influx of the unidirectional Ca2+ surrogates Ba2+ and Mn2+ also exhibit similar responses, Furthermore, while 300 mu M ATP had an inhibitory effect on the thapsigargin-induced capacitative Ca2+ entry, 30 mu M ATP potentiated the response, However, the inhibitory action of 300 mu M ATP was blocked by protein kinase C (PKC) inhibitors, such as GF 109203X and chelerythrine, and the potentiating action of 30 mu M ATP was blocked by protein kinase A (PKA) inhibitors H89 and Rp-cAMPS, The PKC inhibitors also slowed the decay rate of the Ca2+ response induced by 300 mu M ATP, and the PKA inhibitors increased it when induced by 30 mu M ATP. In the measurements of PKA and PKC activity, 30 mu M ATP activates only PKA, while 300 mu M ATP activates both kinases, Taken together, these data suggest that the changes in the ATP-induced Ca2+ response result from differential modulation of ATP-induced capacitative Ca2+ entry by PKC and PKA in HL-60 cells. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLO | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.subject | CALCIUM-ENTRY | - |
dc.subject | EXTRACELLULAR ATP | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | P2-PURINERGIC RECEPTORS | - |
dc.subject | HUMAN-NEUTROPHILS | - |
dc.subject | CA-2+ RELEASE | - |
dc.subject | PC12 CELLS | - |
dc.subject | INFLUX | - |
dc.subject | ACTIVATION | - |
dc.subject | INHIBITION | - |
dc.title | Feedback regulation of ATP-induced Ca2+ signaling in HL-60 cells is mediated by protein kinase A- and C-mediated changes in capacitative Ca2+ entry | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1074/jbc.272.35.21831 | - |
dc.author.google | Lee, H | - |
dc.author.google | Suh, BC | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 272 | - |
dc.relation.issue | 35 | - |
dc.relation.startpage | 21831 | - |
dc.relation.lastpage | 21838 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.272, no.35, pp.21831 - 21838 | - |
dc.identifier.wosid | A1997XT85000026 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 21838 | - |
dc.citation.number | 35 | - |
dc.citation.startPage | 21831 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 272 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0030772444 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 32 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CALCIUM-ENTRY | - |
dc.subject.keywordPlus | EXTRACELLULAR ATP | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | P2-PURINERGIC RECEPTORS | - |
dc.subject.keywordPlus | HUMAN-NEUTROPHILS | - |
dc.subject.keywordPlus | CA-2+ RELEASE | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | INFLUX | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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