DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, SK | - |
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Lee, HS | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T14:13:06Z | - |
dc.date.available | 2016-03-31T14:13:06Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1997-03-19 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.other | 1997-OAK-0000009717 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21355 | - |
dc.description.abstract | We investigated the cross-talk between the histamine and ATP receptors in HL-60 human promyelocytes. While both histamine and extracellular ATP increase intracellular Ca2+ concentration ([Ca2+](i)), we found that histamine treatment causes a decrease in the subsequent ATP-induced Ca2+ release from intracellular stores and Ca2+ influx from extracellular space. In addition, histamine also inhibited the subsequent ATP-induced inositol 1,4,5-trisphosphate (IP3) generation in a manner comparable to the Ca2+ release. However, histamine did not inhibit thapsigargin-induced Ca2+ release and influx, thus indicating that histamine does not directly inhibit the Ca2+ release-activated channel (CRAC). Ca2+ elevation induced by 2'- and 3'-O-(4-benzoylbenzoyl) ATP (BzATP), which does not produce IP3, was also inhibited by treatment with histamine, suggesting the presence of ATP-gated channels that are regulated by histamine. Treatment with dibutyryl cAMP or 8-bromo-cAMP inhibited the subsequent ATP-induced response similar to histamine. Moreover, the incubation of cells with N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89), a protein kinase A inhibitor, abolished histamine's inhibitory effect on the ATP-induced [Ca2+](i) rise and IP3 formation. These results suggest that histamine inhibits both ATP-induced IP3 production and ATP-activated channel opening, through protein kinase A activation. (C) 1997 Elsevier Science B.V. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.subject | histamine | - |
dc.subject | ATP, extracellular | - |
dc.subject | [Ca2+](i) | - |
dc.subject | HL-60 cell | - |
dc.subject | INCREASES CYTOSOLIC CA2+ | - |
dc.subject | HUMAN-NEUTROPHILS | - |
dc.subject | PHOSPHOLIPASE-C | - |
dc.subject | CYCLIC-AMP | - |
dc.subject | PURINERGIC RECEPTORS | - |
dc.subject | EXTRACELLULAR ATP | - |
dc.subject | HL60 CELLS | - |
dc.subject | CATION CHANNELS | - |
dc.subject | DIBUTYRYL-CAMP | - |
dc.subject | CALCIUM-ENTRY | - |
dc.title | Histamine inhibits ATP-induced [Ca2+](i) rise through the activation of protein kinase a in HL-60 cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0014-2999(96)00998-3 | - |
dc.author.google | Song, SK | - |
dc.author.google | Suh, BC | - |
dc.author.google | Lee, HS | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 322 | - |
dc.relation.issue | 2-3 | - |
dc.relation.startpage | 265 | - |
dc.relation.lastpage | 273 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, v.322, no.2-3, pp.265 - 273 | - |
dc.identifier.wosid | A1997WQ85800020 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 273 | - |
dc.citation.number | 2-3 | - |
dc.citation.startPage | 265 | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.citation.volume | 322 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0030906037 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 6 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INCREASES CYTOSOLIC CA2+ | - |
dc.subject.keywordPlus | HUMAN-NEUTROPHILS | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | PURINERGIC RECEPTORS | - |
dc.subject.keywordPlus | EXTRACELLULAR ATP | - |
dc.subject.keywordPlus | HL60 CELLS | - |
dc.subject.keywordPlus | CATION CHANNELS | - |
dc.subject.keywordPlus | DIBUTYRYL-CAMP | - |
dc.subject.keywordPlus | CALCIUM-ENTRY | - |
dc.subject.keywordAuthor | histamine | - |
dc.subject.keywordAuthor | ATP, extracellular | - |
dc.subject.keywordAuthor | [Ca2+](i) | - |
dc.subject.keywordAuthor | HL-60 cell | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.