SYNTHESIS AND BIOACTIVITIES OF HETEROCYCLIC LIPIDS AS PAF ANTAGONISTS .2.
SCIE
SCOPUS
- Title
- SYNTHESIS AND BIOACTIVITIES OF HETEROCYCLIC LIPIDS AS PAF ANTAGONISTS .2.
- Authors
- CHUNG, SK; BAN, SH; KIM, SH; KIM, BE; WOO, SH
- Date Issued
- 1995-05-18
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Conformationally constrained analogues of platelet activating factor incorporating a lipophile and a pyridine-like heterocycle linked to core groups such as 1,1-bis(hydroxymethyl)cyclobutane and 2,4-bis(hydroxymethyl)-oxetane, -thietane and -azetidine skeletons via hydrogen bond acceptors such as ether and/or carbamate have been synthesized, and their in vitro and in vivo bioactivitites have indicated potent and selective PAF antagonism.
- Keywords
- PLATELET-ACTIVATING-FACTOR; FACTOR RECEPTOR; EXPRESSION; CLONING; DESIGN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21783
- DOI
- 10.1016/0960-894X(95)00174-R
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 10, page. 1097 - 1102, 1995-05-18
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- There are no files associated with this item.
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