DOWN-REGULATION OF PHOSPHOLIPASE C-GAMMA-1 DURING THE DIFFERENTIATION OF U937 CELLS
SCIE
SCOPUS
- Title
- DOWN-REGULATION OF PHOSPHOLIPASE C-GAMMA-1 DURING THE DIFFERENTIATION OF U937 CELLS
- Authors
- LEE, YH; LEE, HJ; LEE, SJ; MIN, DS; BAEK, SH; KIM, YS; RYU, SH; SUH, PG
- Date Issued
- 1995-01-23
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- Phospholipase C (PLC)-gamma 1 and -gamma 2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process,which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered. Northern blot analysis showed that the levels of PLC-gamma 1 and -gamma 2 transcripts were not changed. These results suggest that the expression of PLC-gamma 1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.
- Keywords
- DIFFERENTIATION; PMA; PHOSPHOLIPASE C-GAMMA-1; PHOSPHOLIPASE C-GAMMA-2; DOWN-REGULATION; U937 CELL; TYROSINE PHOSPHORYLATION; BOVINE BRAIN; C ISOZYMES; EXPRESSION; LYMPHOCYTES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21856
- DOI
- 10.1016/0014-5793(94)01404-O
- ISSN
- 0014-5793
- Article Type
- Article
- Citation
- FEBS LETTERS, vol. 358, no. 2, page. 105 - 108, 1995-01-23
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- There are no files associated with this item.
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