SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF (4,6-DI-O-PHOSPHONATO-BETA-D-MANNOPYRANOSYL)-METHYLPHOSPHONATE AS AN ANALOG OF 1L-MYO-INOSITOL 1,4,5-TRISPHOSPHATE
SCIE
SCOPUS
- Title
- SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF (4,6-DI-O-PHOSPHONATO-BETA-D-MANNOPYRANOSYL)-METHYLPHOSPHONATE AS AN ANALOG OF 1L-MYO-INOSITOL 1,4,5-TRISPHOSPHATE
- Authors
- CHUNG, SK; MOON, SH
- Date Issued
- 1994-07-04
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- The synthesis of the alpha and beta anomers of the title compound (1) was accomplished from D-mannose. In the key step, the phosphonate analogues of the mannopyranosyl phosphates were prepared by a direct Wadsworth-Emmons condensation of a protected mannose derivative (8) with tetraethyl methylenebisphosphonate under two-phase conditions. In vitro bioassays have shown that the beta anomer (1a> is a potent inhibitor of Ins(1,4,5)P-3 3-kinase and inhibits other enzymes.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21942
- DOI
- 10.1016/0008-6215(94)80020-0
- ISSN
- 0008-6215
- Article Type
- Article
- Citation
- CARBOHYDRATE RESEARCH, vol. 260, no. 1, page. 39 - 50, 1994-07-04
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- There are no files associated with this item.
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