DC Field | Value | Language |
---|---|---|
dc.contributor.author | JANG, SK | - |
dc.contributor.author | KIM, SK | - |
dc.contributor.author | RHO, HM | - |
dc.date.accessioned | 2016-03-31T14:39:02Z | - |
dc.date.available | 2016-03-31T14:39:02Z | - |
dc.date.created | 2009-08-19 | - |
dc.date.issued | 1994-04 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.other | 1994-OAK-0000008885 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21973 | - |
dc.description.abstract | We have previously cloned a mutant hepatitis B virus (HBV) genome which had one thymidine addition in the pre-C region resulting in a frameshift mutation in the pre-C region and fusion of the X and C genes. We constructed plasmids containing serially deleted and/or back-mutated (authentic) pre-C regions to study the effect of the frameshift mutation. COS cells transfected with plasmids containing the frameshifted pre-C region produced a 21K C protein (P21c) but not a 22K partially processed pre-C protein (P22). On the other hand, COS cells transfected with plasmids containing the back-mutated pre-C region produced P22. This result was also observed in HepG2-K8 cells producing the mutant HBV particles. Therefore, the pre-C region of HBV is likely to be non-essential for virus replication. COS cells transfected with the plasmid containing a fused X-C open reading frame (ORF) produced a 40K X-C fusion protein. This X-C fusion protein exerted transcriptional trans-activation. These results suggest that the mutant HBV has a C gene with a defective pre-C region and a fused X-C ORF, and hence cannot synthesize 16K HBeAg (P16e). | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.relation.isPartOf | JOURNAL OF GENERAL VIROLOGY | - |
dc.title | EFFECT OF FRAMESHIFT MUTATION IN THE PRE-C REGION OF HEPATITIS-B VIRUS ON THE X-GENE AND C-GENE | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1099/0022-1317-75-4-917 | - |
dc.author.google | JANG, SK | - |
dc.author.google | KIM, SK | - |
dc.author.google | RHO, HM | - |
dc.relation.volume | 75 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 917 | - |
dc.relation.lastpage | 923 | - |
dc.contributor.id | 10088382 | - |
dc.relation.journal | JOURNAL OF GENERAL VIROLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF GENERAL VIROLOGY, v.75, no.4, pp.917 - 923 | - |
dc.identifier.wosid | A1994NE61200025 | - |
dc.citation.endPage | 923 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 917 | - |
dc.citation.title | JOURNAL OF GENERAL VIROLOGY | - |
dc.citation.volume | 75 | - |
dc.contributor.affiliatedAuthor | JANG, SK | - |
dc.identifier.scopusid | 2-s2.0-0028223011 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 12 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | POSITIVE CHRONIC HEPATITIS | - |
dc.subject.keywordPlus | E-ANTIGEN | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | PRECORE REGION | - |
dc.subject.keywordPlus | NUCLEOTIDE-SEQUENCE | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | CORE ANTIGEN | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Virology | - |
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