Recent advances in cell-penetrating, non-peptide molecular carriers
SCIE
SCOPUS
- Title
- Recent advances in cell-penetrating, non-peptide molecular carriers
- Authors
- Chung, SK; Maiti, KK; Lee, WS
- Date Issued
- 2008-04-16
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- The intracellular delivery of proteins and other bioactive molecules by employing membrane-permeable carrier peptide vectors, e.g. HIV-1 Tat, Antp-HD, and related arginine-rich peptides are well known for a number of years. Because of some real and potential problems associated with these peptide carriers, such as instability due to various endogenous peptidases, uncertain in vivo delivery efficiency, potential neurotoxicity and immunogenicity, an urgent need exists for the development of efficient, non-peptide molecular carriers. This review briefly summarizes the structural characteristics and the delivery properties of the newly developed non-peptide carriers, in particular the ones developed in the author's laboratory, together with their potential as delivery vectors for poorly bioavailable drugs including small molecules, proteins, and nucleotides. (C) 2007 Elsevier B.V. All rights reserved.
- Keywords
- cell-penetration; molecular carrier vectors; organelle selectivity; tissue selectivity; blood-brain barrier; MEMBRANE-PERMEABLE PEPTIDES; ARGININE-RICH PEPTIDES; TAT-FUSION PROTEINS; DRUG-DELIVERY; INTRACELLULAR DELIVERY; TRANSPORTERS; EFFICIENT; TRANSLOCATION; TRANSDUCTION; DESIGN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/22792
- DOI
- 10.1016/J.IJPHARM.20
- ISSN
- 0378-5173
- Article Type
- Article
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 354, no. 1-2, page. 16 - 22, 2008-04-16
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- There are no files associated with this item.
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