DC Field | Value | Language |
---|---|---|
dc.contributor.author | Barwe, SP | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Rajasekaran, SA | - |
dc.contributor.author | Bowie, JU | - |
dc.contributor.author | Rajasekaran, AK | - |
dc.date.accessioned | 2016-04-01T01:44:56Z | - |
dc.date.available | 2016-04-01T01:44:56Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2007-01-19 | - |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.other | 2007-OAK-0000006521 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23617 | - |
dc.description.abstract | Na,K-ATPase is a hetero-oligomer of a and beta-subunits. The Na,K-ATPase beta-subunit (Na,K-beta) is involved in both the regulation of ion transport activity, and in cell-cell adhesion. By structure prediction and evolutionary analysis, we identified two distinct faces on the Na,K-beta transmembrane domain (TMD) that could mediate protein-protein interactions: a glycine zipper motif and a conserved heptad repeat. Here, we show that the heptad repeat face is involved in the hetero-oligomeric interaction of Na,K-beta with Na,K-alpha, and the glycine zipper face is involved in the homo-oligomerization of Na, K-beta. Point mutations in the heptad repeat motif reduced Na,K-beta binding to Na,K-a, and Na,K-ATPase activity. Na,K-beta TMD homo-oligomerized in biological membranes, and mutation of the glycine zipper motif affected oligomerization and cell-cell adhesion. These results provide a structural basis for understanding how Na,K-beta links ion transport and cell-cell adhesion. (c) 2006 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD ELSEVIER SCIENCE L | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.subject | transmembrane domain | - |
dc.subject | heptad repeat motif | - |
dc.subject | GxxxG | - |
dc.subject | glycine zipper | - |
dc.subject | Na,K-ATPase | - |
dc.subject | MEMBRANE-PROTEINS | - |
dc.subject | E-CADHERIN | - |
dc.subject | DIMERIZATION MOTIF | - |
dc.subject | HELIX INTERACTIONS | - |
dc.subject | CELL-MEMBRANES | - |
dc.subject | NA+/K+-ATPASE | - |
dc.subject | GXXXG MOTIF | - |
dc.subject | ASSOCIATION | - |
dc.subject | RESIDUES | - |
dc.subject | PACKING | - |
dc.title | Janus model of the Na,K-ATPase beta-subunit transmembrane domain: Distinct faces mediate alpha/beta assembly and beta-beta homo-oligomerization | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.jmb.2006.10.029 | - |
dc.author.google | Barwe, SP | - |
dc.author.google | Kim, S | - |
dc.author.google | Rajasekaran, SA | - |
dc.author.google | Bowie, JU | - |
dc.author.google | Rajasekaran, AK | - |
dc.relation.volume | 365 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 706 | - |
dc.relation.lastpage | 714 | - |
dc.contributor.id | 10136479 | - |
dc.relation.journal | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR BIOLOGY, v.365, no.3, pp.706 - 714 | - |
dc.identifier.wosid | 000243561500015 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 714 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 706 | - |
dc.citation.title | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.citation.volume | 365 | - |
dc.contributor.affiliatedAuthor | Kim, S | - |
dc.identifier.scopusid | 2-s2.0-33845661568 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 39 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DIMERIZATION MOTIF | - |
dc.subject.keywordPlus | MEMBRANE-PROTEINS | - |
dc.subject.keywordPlus | NA+/K+-ATPASE | - |
dc.subject.keywordPlus | GXXXG MOTIF | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PACKING | - |
dc.subject.keywordPlus | SEGMENT | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordAuthor | transmembrane domain | - |
dc.subject.keywordAuthor | heptad repeat motif | - |
dc.subject.keywordAuthor | GxxxG | - |
dc.subject.keywordAuthor | glycine zipper | - |
dc.subject.keywordAuthor | Na,K-ATPase | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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