DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liang, CY | - |
dc.contributor.author | Feng, PH | - |
dc.contributor.author | Ku, BS | - |
dc.contributor.author | Oh, BH | - |
dc.contributor.author | Jung, JU | - |
dc.date.accessioned | 2016-04-01T01:45:00Z | - |
dc.date.available | 2016-04-01T01:45:00Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2007-01 | - |
dc.identifier.issn | 1554-8627 | - |
dc.identifier.other | 2007-OAK-0000006517 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23619 | - |
dc.description.abstract | Autophagy has a well-documented role in the maintenance of homeostasis and the response to stressful environments and it is often deregulated in various human diseases including cancer. The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway. Previous studies(1) have demonstrated that Beclin 1-PI3KC3-mediated autophagy is negatively regulated by a proto-oncogene Bcl-2. We have recently identified a novel coiled-coil UVRAG tumor suppressor candidate, which positively engages in Beclin 1-dependent autophagy. UVRAG interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenesis. This finding adds a new player to the emerging picture of the autophagy network, underscoring the importance of the coordinated activity between Bcl-2 and UVRAG in the regulation of Beclin 1-PI3KC3-mediated autophagy and tumor cell control. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | LANDES BIOSCIENCE | - |
dc.relation.isPartOf | AUTOPHAGY | - |
dc.subject | UVRAG | - |
dc.subject | autophagy | - |
dc.subject | tumor suppression | - |
dc.subject | Beclin 1 | - |
dc.subject | Bcl-2 | - |
dc.subject | COLON-CANCER | - |
dc.subject | GENE | - |
dc.subject | BECLIN-1 | - |
dc.subject | INHIBITION | - |
dc.subject | SUPPRESSOR | - |
dc.subject | PROTEIN | - |
dc.subject | CLONING | - |
dc.title | UVRAG - A new player in autophagy and tumor cell growth | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4161/auto.3437 | - |
dc.author.google | "Liang, CY | - |
dc.author.google | Feng, PH | - |
dc.author.google | Ku, BS | - |
dc.author.google | Oh, BH | - |
dc.author.google | Jung, JU" | - |
dc.relation.volume | 3 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 69 | - |
dc.relation.lastpage | 71 | - |
dc.relation.journal | AUTOPHAGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | AUTOPHAGY, v.3, no.1, pp.69 - 71 | - |
dc.identifier.wosid | 000243499200021 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 71 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 69 | - |
dc.citation.title | AUTOPHAGY | - |
dc.citation.volume | 3 | - |
dc.contributor.affiliatedAuthor | Oh, BH | - |
dc.identifier.scopusid | 2-s2.0-33846204370 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 46 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BECLIN-1 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordAuthor | UVRAG | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | tumor suppression | - |
dc.subject.keywordAuthor | Beclin 1 | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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