DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, E | - |
dc.contributor.author | Kim, GH | - |
dc.contributor.author | Choi, SC | - |
dc.contributor.author | Han, JK | - |
dc.date.accessioned | 2016-04-01T01:56:56Z | - |
dc.date.available | 2016-04-01T01:56:56Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2006-04-15 | - |
dc.identifier.issn | 0012-1606 | - |
dc.identifier.other | 2006-OAK-0000005875 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24068 | - |
dc.description.abstract | Convergent extension (CE) movements in gastrulation are essential for the establishment of the body axis during early vertebrate development. Although the precise molecular mechanisms of CE movements are not clearly understood, noncanonical Wnt pathway is known to be important for the control of CE movements. Here, we present evidence that PKA is implicated in noncanonical Wnt pathway. Overexpression and specific depiction of PKA inhibit CE movements. PKA depiction also disrupts cell morphology, protrusive activity, and cortical actin formation in dorsal mesodermal cells. Moreover, PKA activity is negatively regulated by major components of planar cell polarity (PCP) pathway. In line with this, overexpression of PKA can rescue the inhibition of CE movements caused by over-expression of these molecules. We also demonstrate that this regulation of PKA activity is dependent upon G alpha i signaling. As a negative component of PCP signaling, PKA inhibits not only the activation of RhoA and JNK but also the Dsh-Daam1-RhoA complex formation which is essential for the regulation of RhoA activity. Together, our study suggests a molecular pathway from Wnt/Dsh/PKA signaling to Rho activation in PCP signaling. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | DEVELOPMENTAL BIOLOGY | - |
dc.subject | Wnt | - |
dc.subject | cAMP-dependent protein kinase (PKA) | - |
dc.subject | convergent extension (CE) movements | - |
dc.subject | Dsh | - |
dc.subject | RhoA | - |
dc.subject | Xenopus embryo | - |
dc.subject | CONVERGENT EXTENSION MOVEMENTS | - |
dc.subject | PROTEIN-KINASE-A | - |
dc.subject | NONCANONICAL WNT PATHWAY | - |
dc.subject | VERTEBRATE GASTRULATION | - |
dc.subject | PLANAR POLARITY | - |
dc.subject | CYCLIC-AMP | - |
dc.subject | CELL MOVEMENTS | - |
dc.subject | AXIS FORMATION | - |
dc.subject | RHO GTPASES | - |
dc.subject | ACTIVATION | - |
dc.title | Role of PKA as a negative regulator of PCP signaling pathway during Xenopus gastrulation movements | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.ydbio.2006.01.011 | - |
dc.author.google | Park, E | - |
dc.author.google | Kim, GH | - |
dc.author.google | Choi, SC | - |
dc.author.google | Han, JK | - |
dc.relation.volume | 292 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 344 | - |
dc.relation.lastpage | 357 | - |
dc.contributor.id | 10138853 | - |
dc.relation.journal | DEVELOPMENTAL BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | DEVELOPMENTAL BIOLOGY, v.292, no.2, pp.344 - 357 | - |
dc.identifier.wosid | 000236947900006 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 357 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 344 | - |
dc.citation.title | DEVELOPMENTAL BIOLOGY | - |
dc.citation.volume | 292 | - |
dc.contributor.affiliatedAuthor | Han, JK | - |
dc.identifier.scopusid | 2-s2.0-33645919975 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 24 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CONVERGENT EXTENSION MOVEMENTS | - |
dc.subject.keywordPlus | NONCANONICAL WNT PATHWAY | - |
dc.subject.keywordPlus | PLANAR POLARITY | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | VERTEBRATE GASTRULATION | - |
dc.subject.keywordPlus | CELL MOVEMENTS | - |
dc.subject.keywordPlus | AXIS FORMATION | - |
dc.subject.keywordPlus | RHO GTPASES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | Wnt | - |
dc.subject.keywordAuthor | cAMP-dependent protein kinase (PKA) | - |
dc.subject.keywordAuthor | convergent extension (CE) movements | - |
dc.subject.keywordAuthor | Dsh | - |
dc.subject.keywordAuthor | RhoA | - |
dc.subject.keywordAuthor | Xenopus embryo | - |
dc.relation.journalWebOfScienceCategory | Developmental Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Developmental Biology | - |
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