DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, DC | - |
dc.contributor.author | Park, YS | - |
dc.contributor.author | Jun, DJ | - |
dc.contributor.author | Hur, EM | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Choi, BH | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-04-01T02:00:23Z | - |
dc.date.available | 2016-04-01T02:00:23Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2006-02-28 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.other | 2006-OAK-0000005688 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24199 | - |
dc.description.abstract | The therapeutic targeting of nicotinic receptors requires the identification of drugs that selectively activate or inhibit a limited range of nicotine acetylcholine receptors (nAChRs). In this study, we identified N-(4-trifluoromethylphenyl)amide group of the synthetic histamine receptor ligands, histamine-trifluoromethyltoluide, that act as potent inhibitors of nAChRs in bovine adrenal chrornaffin cells. Catecholamine secretion induced by the nAChRs agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), was significantly inhibited by histamine-trifluoromethyltoluide. Real time carbon-fiber amperometry confirmed the ability of histamine-trifluoromethyltoluide to inhibit DMPP-induced exocytosis in single chromaffin cells. We also found that histamine-trifluoromethyltoluide inhibited DMPP-induced [Ca2+](i) and [Na+](i) increases, as well as DMPP-induced inward currents in the absence of extracellular calcium. Histamine-trifluoromethyltoluide had no effect on [H-3]nicotine binding or on calcium increases induced by high K+, bradykinin, veratridine, histamine, and benzoylbenzoyl ATP. Among the synthetic histamine receptor ligands, clobenpropit exhibited similarity. In addition, 4'-nitroacetanilide also significantly attenuated nAChR-mediated catecholamine secretion. In conclusion, the N-(4-trifluoromethylphenyl)amide group of the histamine-trifluoromethyltoluide might be the critical moiety in the inhibition of nAChR-mediated CA secretion. (c) 2005 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.subject | catecholamine | - |
dc.subject | DMPP | - |
dc.subject | Ca2+ influx | - |
dc.subject | histamine-trifluoromethyltoluide | - |
dc.subject | nicotinic acetylcholine receptor | - |
dc.subject | chromaffin cells | - |
dc.subject | ADRENAL CHROMAFFIN CELLS | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | PARAVENTRICULAR NUCLEUS | - |
dc.subject | INTRACELLULAR CALCIUM | - |
dc.subject | RELEASE | - |
dc.subject | RATS | - |
dc.subject | GENERATION | - |
dc.subject | CHANNELS | - |
dc.subject | MEDULLA | - |
dc.subject | ANTINOCICEPTION | - |
dc.title | N-(4-trifluoromethylphenyl)amide group of the synthetic histamine receptor agonist inhibits nicotinic acetylcholine receptor-mediated catecholamine secretion | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.bcp.2005.11.021 | - |
dc.author.google | Kim, DC | - |
dc.author.google | Park, YS | - |
dc.author.google | Jun, DJ | - |
dc.author.google | Hur, EM | - |
dc.author.google | Kim, SH | - |
dc.author.google | Choi, BH | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 71 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 670 | - |
dc.relation.lastpage | 682 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | BIOCHEMICAL PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.71, no.5, pp.670 - 682 | - |
dc.identifier.wosid | 000235297300012 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 682 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 670 | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 71 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-31044449304 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ADRENAL CHROMAFFIN CELLS | - |
dc.subject.keywordPlus | PARAVENTRICULAR NUCLEUS | - |
dc.subject.keywordPlus | INTRACELLULAR CALCIUM | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | CHANNELS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | ANTINOCICEPTION | - |
dc.subject.keywordPlus | EPIBATIDINE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordAuthor | catecholamine | - |
dc.subject.keywordAuthor | DMPP | - |
dc.subject.keywordAuthor | Ca2+ influx | - |
dc.subject.keywordAuthor | histamine-trifluoromethyltoluide | - |
dc.subject.keywordAuthor | nicotinic acetylcholine receptor | - |
dc.subject.keywordAuthor | chromaffin cells | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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