DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, DC | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Jeong, MW | - |
dc.contributor.author | Baek, NI | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-04-01T02:04:20Z | - |
dc.date.available | 2016-04-01T02:04:20Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2005-11-11 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2005-OAK-0000005463 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24350 | - |
dc.description.abstract | In microglia, Toll-like receptors have been shown to recognize pathogen-associated molecular patterns and initiate innate immune responses upon interaction with infectious agents. The effect of rottlerin, a PKC-delta specific inhibitor, on TLR-4-mediated signaling was investigated in murine microglia stimulated with lipopolysaccharide and taxol. Pretreatment of microglia cells with rottlerin decreased LPS- and taxol-induced nitric oxide production in a concentration-dependent manner (IC50 = 99.1 +/- 1.5 nM). Through MTT and FACS analysis, we found that the inhibition effect of rottlerin was not due to microglial cell death. Rottlerin pretreatment also attenuated LPS-induced phosphorylation of IkappaB-alpha, nuclear translocation of NF-kappa B, and expression of type 11 nitric oxide synthase. In addition, microglial phagocytosis in response to TLR-4 activation was diminished in which rottlerin was pretreated. Together, these data raise the possibility that certain PKC-delta specific inhibitors can modulate TLR-4-derived signaling and inflammatory target gene expression, and can alter susceptibility to microbial infection and chronic inflammatory diseases in central nervous system. (c) 2005 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | rottlerin | - |
dc.subject | microglia | - |
dc.subject | TLR-4 | - |
dc.subject | nitric oxide | - |
dc.subject | phagocytosis | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | CELLS | - |
dc.subject | EXPRESSION | - |
dc.subject | BRAIN | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | MODULATION | - |
dc.subject | INDUCTION | - |
dc.title | Effect of rottlerin, a PKC-delta inhibitor, on TLR-4-dependent activation of murine microglia | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.09.009 | - |
dc.author.google | Kim, DC | - |
dc.author.google | Kim, SH | - |
dc.author.google | Jeong, MW | - |
dc.author.google | Baek, NI | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 337 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 110 | - |
dc.relation.lastpage | 115 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.337, no.1, pp.110 - 115 | - |
dc.identifier.wosid | 000232584000015 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 115 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 110 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 337 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-25844437421 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 20 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | rottlerin | - |
dc.subject.keywordAuthor | microglia | - |
dc.subject.keywordAuthor | TLR-4 | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | phagocytosis | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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