DC Field | Value | Language |
---|---|---|
dc.contributor.author | Udo, H | - |
dc.contributor.author | Jin, I | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Li, HL | - |
dc.contributor.author | Youn, T | - |
dc.contributor.author | Hawkins, RD | - |
dc.contributor.author | K | - |
dc.contributor.author | el, ER | - |
dc.contributor.author | Bailey, CH | - |
dc.date.accessioned | 2016-04-01T02:13:16Z | - |
dc.date.available | 2016-04-01T02:13:16Z | - |
dc.date.created | 2009-08-10 | - |
dc.date.issued | 2005-03-24 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.other | 2005-OAK-0000004989 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24686 | - |
dc.description.abstract | Application of Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, at the Aplysia sensory to motor neuron synapse blocks long-term facilitation and the associated growth of new sensory neuron varicosities induced by repeated pulses of serotonin (5-HT). We have isolated cDNAs encoding Aplysia Rho, Rac, and Cdc42 and found that Rho and Rac had no effect but that overexpression in sensory neurons of a dominant-negative mutant of ApCdc42 or the CRIB domains of its downstream effectors PAK and N-WASP selectively reduces the long-term changes in synaptic strength and structure. FRET analysis indicates that 5-HT activates ApCdc42 in a subset of varicosities contacting the postsynaptic motor neuron and that this activation is dependent on the PI3K and PLC signaling pathways. The 5-HT-induced activation of ApCdc42 initiates reorganization of the presynaptic actin network leading to the outgrowth of filopodia, some of which are morphological precursors for the learning-related formation of new sensory neuron varicosities. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | NEURON | - |
dc.subject | LONG-TERM FACILITATION | - |
dc.subject | CELL-CELL ADHESION | - |
dc.subject | RHO GTPASES | - |
dc.subject | STRUCTURAL-CHANGES | - |
dc.subject | DEPOLYMERIZING PROTEIN | - |
dc.subject | P21-ACTIVATED KINASE | - |
dc.subject | DENDRITIC SPINES | - |
dc.subject | MEMORY STORAGE | - |
dc.subject | RAC | - |
dc.subject | PLASTICITY | - |
dc.title | Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.NEURON.2005.01.044 | - |
dc.author.google | Udo, H | - |
dc.author.google | Jin, I | - |
dc.author.google | Kim, JH | - |
dc.author.google | Li, HL | - |
dc.author.google | Youn, T | - |
dc.author.google | Hawkins, RD | - |
dc.author.google | Kandel, ER | - |
dc.author.google | Bailey, CH | - |
dc.relation.volume | 45 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 887 | - |
dc.relation.lastpage | 901 | - |
dc.contributor.id | 10114767 | - |
dc.relation.journal | NEURON | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NEURON, v.45, no.6, pp.887 - 901 | - |
dc.identifier.wosid | 000228031300010 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 901 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 887 | - |
dc.citation.title | NEURON | - |
dc.citation.volume | 45 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.identifier.scopusid | 2-s2.0-15444378906 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 79 | - |
dc.description.scptc | 81 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LONG-TERM FACILITATION | - |
dc.subject.keywordPlus | STRUCTURAL-CHANGES | - |
dc.subject.keywordPlus | RHO GTPASES | - |
dc.subject.keywordPlus | DEPOLYMERIZING PROTEIN | - |
dc.subject.keywordPlus | P21-ACTIVATED KINASE | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | RAC | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | SYNAPSES | - |
dc.subject.keywordPlus | TARGET | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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