DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, C | - |
dc.contributor.author | Cho, WK | - |
dc.contributor.author | Song, KM | - |
dc.contributor.author | Cook, C | - |
dc.contributor.author | Yoon, TY | - |
dc.contributor.author | Ban, C | - |
dc.contributor.author | Fishel, R | - |
dc.contributor.author | Lee, JB | - |
dc.date.accessioned | 2016-04-01T02:20:58Z | - |
dc.date.available | 2016-04-01T02:20:58Z | - |
dc.date.created | 2011-03-28 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 1545-9985 | - |
dc.identifier.other | 2011-OAK-0000023128 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24958 | - |
dc.description.abstract | Single-molecule trajectory analysis has suggested DNA repair proteins may carry out a one-dimensional (1D) search on naked DNA encompassing > 10,000 nucleotides. Organized cellular DNA (chromatin) presents substantial barriers to such lengthy searches. Using dynamic single-molecule fluorescence resonance energy transfer, we determined that the mismatch repair (MMR) initiation protein MutS forms a transient clamp that scans duplex DNA for mismatched nucleotides by 1D diffusion for 1 s (similar to 700 base pairs) while in continuous rotational contact with the DNA. Mismatch identification provokes ATP binding (3 s) that induces distinctly different MutS sliding clamps with unusual stability on DNA (similar to 600 s), which may be released by adjacent single-stranded DNA (ssDNA). These observations suggest that ATP transforms short-lived MutS lesion scanning clamps into highly stable MMR signaling clamps that are capable of competing with chromatin and recruiting MMR machinery, yet are recycled by ssDNA excision tracts. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE STRUCTURAL & MOLECULAR BIOLOGY | - |
dc.subject | ESCHERICHIA-COLI MUTS | - |
dc.subject | NONPOLYPOSIS COLORECTAL-CANCER | - |
dc.subject | DNA MISMATCH | - |
dc.subject | SINGLE-MOLECULE | - |
dc.subject | FLUORESCENCE SPECTROSCOPY | - |
dc.subject | RECOGNITION COMPLEX | - |
dc.subject | HETERODUPLEX DNA | - |
dc.subject | SLIDING CLAMP | - |
dc.subject | PROTEIN MUTS | - |
dc.subject | HMSH2-HMSH6 | - |
dc.title | MutS switches between two fundamentally distinct clamps during mismatch repair | - |
dc.type | Article | - |
dc.contributor.college | 물리학과 | - |
dc.identifier.doi | 10.1038/NSMB.2009 | - |
dc.author.google | Jeong, C | - |
dc.author.google | Cho, WK | - |
dc.author.google | Song, KM | - |
dc.author.google | Cook, C | - |
dc.author.google | Yoon, TY | - |
dc.author.google | Ban, C | - |
dc.author.google | Fishel, R | - |
dc.author.google | Lee, JB | - |
dc.relation.volume | 18 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 379 | - |
dc.relation.lastpage | U174 | - |
dc.contributor.id | 10171158 | - |
dc.relation.journal | NATURE STRUCTURAL AND MOLECULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE STRUCTURAL & MOLECULAR BIOLOGY, v.18, no.3, pp.379 - U174 | - |
dc.identifier.wosid | 000288072200021 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | U174 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 379 | - |
dc.citation.title | NATURE STRUCTURAL & MOLECULAR BIOLOGY | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Ban, C | - |
dc.contributor.affiliatedAuthor | Lee, JB | - |
dc.identifier.scopusid | 2-s2.0-79952363840 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 77 | - |
dc.description.scptc | 68 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI MUTS | - |
dc.subject.keywordPlus | NONPOLYPOSIS COLORECTAL-CANCER | - |
dc.subject.keywordPlus | DNA MISMATCH | - |
dc.subject.keywordPlus | SINGLE-MOLECULE | - |
dc.subject.keywordPlus | FLUORESCENCE SPECTROSCOPY | - |
dc.subject.keywordPlus | RECOGNITION COMPLEX | - |
dc.subject.keywordPlus | HETERODUPLEX DNA | - |
dc.subject.keywordPlus | SLIDING CLAMP | - |
dc.subject.keywordPlus | PROTEIN MUTS | - |
dc.subject.keywordPlus | HMSH2-HMSH6 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.