DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Hwang, AB | - |
dc.contributor.author | Kenyon, C | - |
dc.date.accessioned | 2016-04-01T02:28:06Z | - |
dc.date.available | 2016-04-01T02:28:06Z | - |
dc.date.created | 2011-01-13 | - |
dc.date.issued | 2010-12-07 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.other | 2011-OAK-0000022574 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25189 | - |
dc.description.abstract | A mild inhibition of mitochondrial respiration extends the life span of many organisms, including yeast, worms, flies, and mice [1-10], but the underlying mechanism is unknown. One environmental condition that reduces rates of respiration is hypoxia (low oxygen). Thus, it is possible that mechanisms that sense oxygen play a role in the longevity response to reduced respiration. The hypoxia-inducible factor HIF-1 is a highly conserved transcription factor that activates genes that promote survival during hypoxia [11, 12]. In this study, we show that inhibition of respiration in C. elegans can promote longevity by activating HIF-1. Through genome-wide screening, we found that RNA interference (RNAi) knockdown of many genes encoding respiratory-chain components induced hif-1-dependent transcription. Moreover, HIF-1 was required for the extended life spans of clk-1 and isp-1 mutants, which have reduced rates of respiration [1, 4, 13]. Inhibiting respiration appears to activate HIF-1 by elevating the level of reactive oxygen species (ROS). We found that ROS are increased in respiration mutants and that mild increases in ROS can stimulate HIF-1 to activate gene expression and promote longevity. In this way, HIF-1 appears to link respiratory stress in the mitochondria to a nuclear transcriptional response that promotes longevity. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CURRENT BIOLOGY | - |
dc.subject | HYPOXIA-INDUCIBLE FACTOR | - |
dc.subject | CAENORHABDITIS-ELEGANS | - |
dc.subject | LONGEVITY | - |
dc.subject | GENE | - |
dc.subject | MICE | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | DETERMINANT | - |
dc.subject | BEHAVIOR | - |
dc.subject | NEMATODE | - |
dc.subject | MUTANTS | - |
dc.title | Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity | - |
dc.type | Article | - |
dc.contributor.college | 정보전자융합공학부 | - |
dc.identifier.doi | 10.1016/J.CUB.2010.10.057 | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Hwang, AB | - |
dc.author.google | Kenyon, C | - |
dc.relation.volume | 20 | - |
dc.relation.issue | 23 | - |
dc.relation.startpage | 2131 | - |
dc.relation.lastpage | 2136 | - |
dc.contributor.id | 10201212 | - |
dc.relation.journal | CURRENT BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CURRENT BIOLOGY, v.20, no.23, pp.2131 - 2136 | - |
dc.identifier.wosid | 000285213500028 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 2136 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 2131 | - |
dc.citation.title | CURRENT BIOLOGY | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Lee, SJ | - |
dc.identifier.scopusid | 2-s2.0-78650177082 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 247 | - |
dc.description.scptc | 225 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | DETERMINANT | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
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