DC Field | Value | Language |
---|---|---|
dc.contributor.author | Namgung, R | - |
dc.contributor.author | Brumbach, JH | - |
dc.contributor.author | Jeong, JH | - |
dc.contributor.author | Yockman, JW | - |
dc.contributor.author | Kim, SW | - |
dc.contributor.author | Lin, C | - |
dc.contributor.author | Zhong, ZY | - |
dc.contributor.author | Feijen, J | - |
dc.contributor.author | Engbersen, JFJ | - |
dc.contributor.author | Kim, WJ | - |
dc.date.accessioned | 2016-04-01T02:41:35Z | - |
dc.date.available | 2016-04-01T02:41:35Z | - |
dc.date.created | 2010-11-24 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.other | 2010-OAK-0000021969 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/25597 | - |
dc.description.abstract | A bioreducible poly(amido amine) (SS-PAA) gene carrier, known as poly (amido-butanol) (pABOL), was used to transfect a variety of cancer and non-cancer cell lines. To obtain cancer-specific transgene expression for therapeutic efficiency in cancer treatment, we constructed survivin-inducible plasmid DNA expressing the soluble VEGF receptor, sFlt-1, downstream of the survivin promoter (pSUR-sFlt-1). Cancer-specific expression of sFlt-1 was observed in the mouse renal carcinoma (RENCA) cell line. pABOL enhanced the efficiency of gene delivery compared to traditional carriers used in the past. Thus, a dual bio-responsive gene delivery system was developed by using bioreducible p(ABOL) for enhanced intracellular gene delivery and survivin-inducible gene expression system (pSUR-sFlt-1 or pSUR-Luc reporter gene) that demonstrates increased gene expression in cancer that has advantages over current gene delivery systems. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.relation.isPartOf | BIOTECHNOLOGY LETTERS | - |
dc.subject | Dual bio-responsive | - |
dc.subject | Gene therapy | - |
dc.subject | Reducible polymer | - |
dc.subject | Survivin | - |
dc.subject | Tumor cells | - |
dc.subject | ONCOLYTIC ADENOVIRUS | - |
dc.subject | DISULFIDE LINKAGES | - |
dc.subject | MOUSE SURVIVIN | - |
dc.subject | CANCER | - |
dc.subject | APOPTOSIS | - |
dc.subject | PROMOTER | - |
dc.subject | INHIBITION | - |
dc.subject | EXPRESSION | - |
dc.subject | COMPLEXES | - |
dc.subject | THERAPY | - |
dc.title | Dual bio-responsive gene delivery via reducible poly(amido amine) and survivin-inducible plasmid DNA | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1007/S10529-010-0219-7 | - |
dc.author.google | Namgung, R | - |
dc.author.google | Brumbach, JH | - |
dc.author.google | Jeong, JH | - |
dc.author.google | Yockman, JW | - |
dc.author.google | Kim, SW | - |
dc.author.google | Lin, C | - |
dc.author.google | Zhong, ZY | - |
dc.author.google | Feijen, J | - |
dc.author.google | Engbersen, JFJ | - |
dc.author.google | Kim, WJ | - |
dc.relation.volume | 32 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 755 | - |
dc.relation.lastpage | 764 | - |
dc.contributor.id | 10135304 | - |
dc.relation.journal | BIOTECHNOLOGY LETTERS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY LETTERS, v.32, no.6, pp.755 - 764 | - |
dc.identifier.wosid | 000277411100004 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 764 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 755 | - |
dc.citation.title | BIOTECHNOLOGY LETTERS | - |
dc.citation.volume | 32 | - |
dc.contributor.affiliatedAuthor | Kim, WJ | - |
dc.identifier.scopusid | 2-s2.0-77952126937 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 11 | - |
dc.description.scptc | 12 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ONCOLYTIC ADENOVIRUS | - |
dc.subject.keywordPlus | DISULFIDE LINKAGES | - |
dc.subject.keywordPlus | MOUSE SURVIVIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Dual bio-responsive | - |
dc.subject.keywordAuthor | Gene therapy | - |
dc.subject.keywordAuthor | Reducible polymer | - |
dc.subject.keywordAuthor | Survivin | - |
dc.subject.keywordAuthor | Tumor cells | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
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