ConPlex: a server for the evolutionary conservation analysis of protein complex structures
SCIE
SCOPUS
- Title
- ConPlex: a server for the evolutionary conservation analysis of protein complex structures
- Authors
- Choi, YS; Han, SK; Kim, J; Yang, JS; Jeon, J; Ryu, SH; Kim, S
- Date Issued
- 2010-07
- Publisher
- OXFORD UNIV PRESS
- Abstract
- Evolutionary conservation analyses are important for the identification of protein-protein interactions. For protein complex structures, sequence conservation has been applied to determine protein oligomerization states, to characterize native interfaces from non-specific crystal contacts, and to discriminate near-native structures from docking artifacts. However, a user-friendly web-based service for evolutionary conservation analysis of protein complexes has not been available. Therefore, we developed ConPlex (http://sbi.postech.ac.kr/ConPlex/) a web application that enables evolutionary conservation analyses of protein interactions within protein quaternary structures. Users provide protein complex structures; ConPlex automatically identifies protein interfaces and carries out evolutionary conservation analyses for the interface regions. Moreover, ConPlex allows the results of the residue-specific conservation analysis to be displayed on the protein complex structure and provides several options to customize the display output to fit each user's needs. We believe that ConPlex offers a convenient platform to analyze protein complex structures based on evolutionary conservation of protein-protein interface residues.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/25688
- DOI
- 10.1093/NAR/GKQ328
- ISSN
- 0305-1048
- Article Type
- Article
- Citation
- NUCLEIC ACIDS RESEARCH, vol. 38, no. SUPPL. 2, page. W450 - W456, 2010-07
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