Trifurcate feed-forward regulation of age-dependent cell death involving miR164 in Arabidopsis
SCIE
SCOPUS
- Title
- Trifurcate feed-forward regulation of age-dependent cell death involving miR164 in Arabidopsis
- Authors
- Kim, JH; Woo, HR; Kim, J; Lim, PO; Lee, IC; Choi, SH; Hwang, D; Nam, HG
- Date Issued
- 2009-02-20
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Abstract
- Aging induces gradual yet massive cell death in higher organisms, including annual plants. Even so, the underlying regulatory mechanisms are barely known, despite the long- standing interest in this topic. Here, we demonstrate that ORE1, which is a NAC ( NAM, ATAF, and CUC) transcription factor, positively regulates aging- induced cell death in Arabidopsis leaves. ORE1 expression is up- regulated concurrently with leaf aging by EIN2 but is negatively regulated by miR164. miR164 expression gradually decreases with aging through negative regulation by EIN2, which leads to the elaborate up- regulation of ORE1 expression. However, EIN2 still contributes to aging- induced cell death in the absence of ORE1. The trifurcate feed- forward pathway involving ORE1, miR164, and EIN2 provides a highly robust regulation to ensure that aging induces cell death in Arabidopsis leaves.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/26145
- DOI
- 10.1126/SCIENCE.1166
- ISSN
- 0036-8075
- Article Type
- Article
- Citation
- SCIENCE, vol. 323, no. 5917, page. 1053 - 1057, 2009-02-20
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- There are no files associated with this item.
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