Hybrid superparamagnetic iron oxide nanoparticle-branched polyethylenimine magnetoplexes for gene transfection of vascular endothelial cells
SCIE
SCOPUS
- Title
- Hybrid superparamagnetic iron oxide nanoparticle-branched polyethylenimine magnetoplexes for gene transfection of vascular endothelial cells
- Authors
- Namgung, R; Singha, K; Yu, MK; Jon, S; Kim, YS; Ahn, Y; Park, IK; Kim, WJ
- Date Issued
- 2010-05
- Publisher
- ELSEVIER SCI LTD
- Abstract
- The work demonstrated the development of thermally cross-linked superparamagnetic nanomaterial which possessed polyethylene glycol moiety and covalently linked branched polyethylenimine (BPEI), and exhibited highly efficient magnetofection even under serum conditioned media. The study showed its high anti-biofouling, cell viability and serum stability and thus revealed a potential magnetic nanoparticle-mediated targeted gene delivery system. This superparamagnetic particle mediated rapid and efficient transfection in primary vascular endothelial cells (HUVEC) successfully inhibits expression of PAI-1 which is responsible for various vascular dysfunctions such as vascular inflammation and atherosclerosis and thereby provides a potential strategy to transfect highly sensitive HUVEC. The sequential steps for the enhanced magnetofection had been studied by monitoring cellular uptake with the aid of confocal microscopy. (C) 2010 Elsevier Ltd. All rights reserved.
- Keywords
- Magnetofection; Superparamagnetic iron oxide; Polyethylenimine; Gene delivery; Atherosclerosis; BIODEGRADABLE POLYMERIC NANOPARTICLES; IN-VIVO; THERAPY PROGRESS; MAGNETIC FORCE; DNA DELIVERY; ATHEROSCLEROSIS; MAGNETOFECTION; TRANSDUCTION; ULTRASOUND; PROSPECTS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/26217
- DOI
- 10.1016/J.BIOMATERIALS.2010.01.123
- ISSN
- 0142-9612
- Article Type
- Article
- Citation
- BIOMATERIALS, vol. 31, no. 14, page. 4204 - 4213, 2010-05
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- There are no files associated with this item.
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