DC Field | Value | Language |
---|---|---|
dc.contributor.author | Vyas, JM | - |
dc.contributor.author | Kim, YM | - |
dc.contributor.author | Artavanis-Tsakonas, K | - |
dc.contributor.author | Love, JC | - |
dc.contributor.author | Van der Veen, AG | - |
dc.contributor.author | Ploegh, HL | - |
dc.date.accessioned | 2016-04-01T03:05:29Z | - |
dc.date.available | 2016-04-01T03:05:29Z | - |
dc.date.created | 2010-11-24 | - |
dc.date.issued | 2007-06-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2010-OAK-0000020756 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26240 | - |
dc.description.abstract | Immature dendritic cells (DCs) capture exogenous Ags in the periphery for eventual processing in endolysosomes. Upon maturation by TLR agonists, DCs deliver peptide-loaded class II MHC molecules from these compartments to the cell surface via long tubular structures (endolysosomal tubules). The nature and rules that govern the movement of these DC compartments are unknown. In this study, we demonstrate that the tubules contain multiple proteins including the class II MHC molecules and LAMP1, a lysosomal resident protein, as well as CD63 and CD82, members of the tetraspanin family. Endolysosomal tubules can be stained with acidotropic dyes, indicating that they are extensions of lysosomes. However, the proper trafficking of class II MHC molecules themselves is not necessary for endolysosomal tubule formation. DCs lacking MyD88 can also form endolysosomal tubules, demonstrating that MyD88-dependent TLR activation is not necessary for the formation of this compartment. Endolysosomal tubules in DCs exhibit dynamic and saltatory movement, including bidirectional travel. Measured velocities are consistent with motor-based movement along microtubules. Indeed, nocodazole causes the collapse of endolysosomal tubules. In addition to its association with microtubules, endolysosomal tubules follow the plus ends of microtubules as visualized in primary DCs expressing end binding protein 1 (EB1)-enhanced GFP. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | IMMUNOLOGICAL SYNAPSE | - |
dc.subject | INVARIANT CHAIN | - |
dc.subject | TETRASPAN MICRODOMAINS | - |
dc.subject | MULTIVESICULAR BODIES | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | CUTTING EDGE | - |
dc.subject | MATURATION | - |
dc.subject | TRANSPORT | - |
dc.subject | LYSOSOMES | - |
dc.title | Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.4049/jimmunol.178.11.7199 | - |
dc.author.google | Vyas, JM | - |
dc.author.google | Kim, YM | - |
dc.author.google | Artavanis-Tsakonas, K | - |
dc.author.google | Love, JC | - |
dc.author.google | Van der Veen, AG | - |
dc.author.google | Ploegh, HL | - |
dc.relation.volume | 178 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 7199 | - |
dc.relation.lastpage | 7210PG 12 | - |
dc.contributor.id | 10608366 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.178, no.11, pp.7199 - 7210PG 12 | - |
dc.identifier.wosid | 000246896300061 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 7210PG 12 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 7199 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 178 | - |
dc.contributor.affiliatedAuthor | Kim, YM | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 71 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | INVARIANT CHAIN | - |
dc.subject.keywordPlus | IMMUNOLOGICAL SYNAPSE | - |
dc.subject.keywordPlus | MULTIVESICULAR BODIES | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.