DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, YM | - |
dc.contributor.author | Kim, JK | - |
dc.contributor.author | Choi, Y | - |
dc.contributor.author | Choi, S | - |
dc.contributor.author | Yoo, JY | - |
dc.date.accessioned | 2016-04-01T03:14:13Z | - |
dc.date.available | 2016-04-01T03:14:13Z | - |
dc.date.created | 2010-05-01 | - |
dc.date.issued | 2009-09 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | 2010-OAK-0000020474 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/26422 | - |
dc.description.abstract | The comprehensive identification of functional transcription factor binding sites (TFBSs) is an important step in understanding complex transcriptional regulatory networks. This study presents a motif-based comparative approach, STAT-Finder, for identifying functional DNA binding sites of STAT3 transcription factor. STAT-Finder combines STAT-Scanner, which was designed to predict functional STAT TFBSs with improved sensitivity, and a motif-based alignment to minimize false positive prediction rates. Using two reference sets containing promoter sequences of known STAT3 target genes, STAT-Finder identified functional STAT3 TFBSs with enhanced prediction efficiency and sensitivity relative to other conventional TFBS prediction tools. In addition, STAT-Finder identified novel STAT3 target genes among a group of genes that are over-expressed in human cancer cells. The binding of STAT3 to the predicted TFBSs was also experimentally confirmed through chromatin immunoprecipitation. Our proposed method provides a systematic approach to the prediction of functional TFBSs that can be applied to other TFs. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PLoS | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.title | Prediction and experimental validation of novel STAT3 target genes in human cancer cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1371/journal.pone.0006911 | - |
dc.author.google | Oh, YM | - |
dc.author.google | Kim, JK | - |
dc.author.google | Choi, Y | - |
dc.author.google | Choi, S | - |
dc.author.google | Yoo, JY | - |
dc.relation.volume | 4 | - |
dc.relation.issue | 9 | - |
dc.relation.startpage | E6911 | - |
dc.relation.lastpage | E6911 | - |
dc.contributor.id | 10114821 | - |
dc.relation.journal | PLOS ONE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.4, no.9 | - |
dc.identifier.wosid | 000269622100014 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.number | 9 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 4 | - |
dc.contributor.affiliatedAuthor | Kim, JK | - |
dc.contributor.affiliatedAuthor | Yoo, JY | - |
dc.identifier.scopusid | 2-s2.0-70249138359 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 17 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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