DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, H | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Kim, DP | - |
dc.date.accessioned | 2016-04-01T08:05:36Z | - |
dc.date.available | 2016-04-01T08:05:36Z | - |
dc.date.created | 2016-02-26 | - |
dc.date.issued | 2015-02-02 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.other | 2015-OAK-0000032011 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/27209 | - |
dc.description.abstract | The synthesis of pharmaceutical compounds via short-lived intermediates in a microreactor is attractive, because of the fast flow and high throughput. Additionally, intermediates can be utilized sequentially to efficiently build up a library in a short time. Here we present an integrated microfluidic synthesis of biologically active thioquinazolinone libraries. Generation of o-lithiophenyl isothiocyanate and subsequent reaction with aryl isocyanate is optimized by controlling the residence time in the microreactor to 16ms at room temperature. Various S-benzylic thioquinazolinone derivatives are synthesized within 10s in high yields (75-98%) at room temperature. These three-step reactions involve two organolithium intermediates, an isothiocyanate-functionalized aryllithium intermediate, and a subsequent lithium thiolate intermediate. We also demonstrate the gram-scale synthesis of a multifunctionalized thioquinazolinone in the microfluidic device with a high yield (91%) and productivity (1.25g in 5min). | - |
dc.description.statementofresponsibility | x | - |
dc.language | English | - |
dc.publisher | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.relation.isPartOf | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.title | Integrated One-Flow Synthesis of Heterocyclic Thioquinazolinones through Serial Microreactions with Two Organolithium Intermediates | - |
dc.type | Article | - |
dc.contributor.college | 화학공학과 | - |
dc.identifier.doi | 10.1002/ANIE.201410062 | - |
dc.author.google | Kim H. | - |
dc.author.google | Lee H.-J. | - |
dc.author.google | Kim D.-P. | - |
dc.relation.volume | 54 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 1877 | - |
dc.relation.lastpage | 1880 | - |
dc.contributor.id | 10054896 | - |
dc.relation.journal | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.54, no.6, pp.1877 - 1880 | - |
dc.identifier.wosid | 000349209200036 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 1880 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1877 | - |
dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.volume | 54 | - |
dc.contributor.affiliatedAuthor | Kim, DP | - |
dc.identifier.scopusid | 2-s2.0-84963932950 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 23 | - |
dc.description.scptc | 7 | * |
dc.date.scptcdate | 2017-08-235 | * |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ORGANIC-SYNTHESIS | - |
dc.subject.keywordPlus | FLASH CHEMISTRY | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | TECHNOLOGY | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | LIBRARY | - |
dc.subject.keywordAuthor | biologically active compounds | - |
dc.subject.keywordAuthor | microreactors | - |
dc.subject.keywordAuthor | organolithium compounds | - |
dc.subject.keywordAuthor | reactive intermediates | - |
dc.subject.keywordAuthor | thioquinazolinones | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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